Drug interactions When used with other sedative–hypnotics or alcohol, the benzodiazepines will produce additive central nervous system depression. Many benzodiazepines are metabolized by the cytochrome P450 (CYP) enzyme designated CYP3A4. CYP3A4 is inhibited by grapefruit juice and by drugs such as ...
Drug interactions When used with other sedative–hypnotics or alcohol, the benzodiazepines will produce additive central nervous system depression. Many benzodiazepines are metabolized by the cytochrome P450 (CYP) enzyme designated CYP3A4. CYP3A4 is inhibited by grapefruit juice and by drugs such as ...