Grapefruit juice / CYP2D6: clarifying a common misconceptionMany of you probably know that grapefruit juice (GFJ) is a potentiator of many recreational , including benzodiazepines, , and others. This has been confirmed through many studies and countless experience reports....
"grapefruit and grapefruit juice can interact with several medications, including those that treat conditions like high cholesterol and high blood pressure ," goscilo says. if you're taking statins and benzodiazepines, you may need to skip the grapefruit. "before you start a new medication, co...
Grapefruit and grapefruit juice can change the way some medications work, including prescription drugs that treat high blood pressure, abnormal heart rhythms, Crohn's disease, or ulcerative colitis. Other drugs, including some antianxiety drugs, antihistamines, and organ-transplant rejection drugs also...
When grapefruit juice is taken with certain drugs, it might pose a health threat. Grapefruit juice and grapefruits, can interact negatively with medications used for high blood pressure, high cholesterol, and depression. Some of these drugs include calcium channel blockers, statins, immunosuppressan...
ranging from 5% to 30% may be affected to a greater degree by grapefruit juice.2 Drugs that interact with grapefruit juice include antiepileptic agents, antimicrobial agents, benzodiazepines, calcium channel blockers, HMG-CoA reductase inhibitors, hormones, immunosuppressant agents, and others. Reporte...
Grapefruit juice (GFJ) compounds, mainly naringin, bergamottin, and 6,7-dihydroxybergamottin (DHB), inhibit intestinal CYP3A4 enzymes, which are mediated by the metabolic processes of many drugs and result in the interaction between GFJ and drugs that are CYP3A4 substrates when...
Some drugs demonstrate a significantly greater (up to 3-fold) mean oral bioavailability on coadministration with grapefruit juice. With some calcium antagonists, the benzodiazepines midazolam and triazolam and the antihistamine terfenadine, changes in bioavailability are accompanied by altered drug action....