Grapefruit juice / CYP2D6: clarifying a common misconceptionMany of you probably know that grapefruit juice (GFJ) is a potentiator of many recreational , including benzodiazepines, , and others. This has been confirmed through many studies and countless experience reports....
Grapefruit juice is consumed widely in today's health conscious world as a protector against cardiovascular diseases and cancers. It has however, been found to be an inhibitor of the intestinal cytochrome P – 450 3A4 system, which is responsible for the first pass metabolism of many drugs. ...
Although grapefruit is considered a very healthy fruit, particularly when consumed whole rather than juiced, some people may want to avoid this citrus fruit altogether. "Grapefruit and grapefruit juice can interact with several medications, including those that treat conditions like highcholesterolandhi...
Grapefruit and grapefruit juice can change the way some medications work, including prescription drugs that treat high blood pressure, abnormal heart rhythms, Crohn's disease, orulcerative colitis. Other drugs, including some antianxiety drugs, antihistamines, and organ-transplant rejection drugs also ...
have expected for the doses they were taking,” he says. This was true of both the control and experimental groups. Bailey checked every possible thing that could have gone wrong—his figures, whether the pharmacist gave him the wrong dosage—but nothing was off. Except the grapefruit juice...
drugs, it might pose a health threat. Grapefruit juice and grapefruits, can interact negatively with medications used for high blood pressure, high cholesterol, and depression. Some of these drugs include calcium channel blockers, statins, immunosuppressants, benzodiazepines, beta-blockers, and ...
ranging from 5% to 30% may be affected to a greater degree by grapefruit juice.2 Drugs that interact with grapefruit juice include antiepileptic agents, antimicrobial agents, benzodiazepines, calcium channel blockers, HMG-CoA reductase inhibitors, hormones, immunosuppressant agents, and others. Reporte...
Some calcium channel antagonists, benzodiazepines, HMG-CoA reductase inhibitors and cyclosporine are the most affected drugs. A single exposure to one glass of the juice can usually produce the maximal magnitude of the interaction. The data available so far, concerning this interaction and its ...
Some drugs demonstrate a significantly greater (up to 3-fold) mean oral bioavailability on coadministration with grapefruit juice. With some calcium antagonists, the benzodiazepines midazolam and triazolam and the antihistamine terfenadine, changes in bioavailability are accompanied by altered drug action....
Grapefruit juice (GFJ) compounds, mainly naringin, bergamottin, and 6,7-dihydroxybergamottin (DHB), inhibit intestinal CYP3A4 enzymes, which are mediated by the metabolic processes of many drugs and result in the interaction between GFJ and drugs that are CYP3A4 substrates whe...