INTRODUCTION: Since their initial discovery in 1989, grapefruit juice (GFJ)-drug interactions have received extensive interest from the scientific, medical, regulatory and lay communities. Although knowledge regarding the effects of GFJ on drug disposition continues to expand, the list of drugs studied...
Medications and food are often taken together. Linking drug administration to a regular event like a meal can improve the patient’s adherence to the treatment regimen, especially in the elderly(1). However, concomitant drug and food intake create the opportunity for an interaction that may change...
Understanding the grapefruit-drug interaction. 来自 NCBI 喜欢 0 阅读量: 20 作者: D Flanagan 摘要: The inhibitory interaction of grapefruit juice and CYP3A4 medication metabolism was discovered in 1989. CYP3A4 enzymes are responsible for the metabolism of more than 60% of orally-administered ...
INTRODUCTION: Since their initial discovery in 1989, grapefruit juice (GFJ)-drug interactions have received extensive interest from the scientific, medical, regulatory and lay communities. Although knowledge regarding the effects of GFJ on drug disposition continues to expand, the list of drugs studied...
There is more to the grapefruit drug interaction than eating one kind of fruit. Prescribers, pharmacists, direct-to-consumer advertising, and patient leaflets mention grapefruit-induced drug interactions with a variety of common medications. For example, grapefruit can increase atorvastatin (among ...
If that sounds confusing, consider that the severity of any grapefruit-medication interaction depends on the amount consumed, the particular drug in question, and your own unique metabolic response to that drug (and to the grapefruit, for that matter). ...
This is not a complete list. You can visit Drugs.com where they have a drug interaction checker you can utilize to check your medications for interactions including grapefruit. Remember: Do not stop taking your medication without consulting your clinician first. ...
The extent of the interaction can be different depending on the person, the drug, and the amount of grapefruit juice you drink or fruit you eat. Some people may not experience any problems with it at all. Love grapefruit and don’t want to cut it out?
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Grapefruit-juice-based beverage preparation method for the elimination of drug absorption interactiondoi:US7550167 B1A method is provided for producing a grapefruit-juice-based beverage that does not contain compounds in sufficient quantity to inhibit the intestinal CYP3A4 enzyme in vivo. The method ...