[1] BCL2: A Promising Cancer Therapeutic Target. Biochimica et Biophysica Acta, Reviews on Cancer 2017, 1868, 309-314.[2] BCL-2 protein family: attractive targets for cancer therapy. Apoptosis 2023, 28, 20-38.
内源性凋亡途径 由于BCL-2介导的对内源性凋亡的抵抗是恶性肿瘤的标志，靶向抗凋亡BCL-2蛋白也是癌症治...
In the mitochondrial pathway, the Bcl-2 family proteins are perhaps the most important regulators. These proteins can also be responsible for bridging signals from the death-receptor pathway to the mitochondrial pathway. The Bcl-2 family of proteins consists of both anti-apoptosis and pro-apoptosis...
Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells 通讯作者(Correspondence):Jonathan A. Garlick Research:…
protein decided life versus death, respectively. In the context of the more complicated interactions between the expanded families of BCL-2 proteins the basic posit of the rheostat model remains relevant. Ultimately, the fate of the cell is decided by the interactions between the BCL-2 family ...
[4] Warren CFA, Wong-Brown MW, Bowden NA. BCL-2 family isoforms in apoptosis and cancer. Cell Death Dis. 2019 Feb 21;10(3):177. doi: 10.1038/s41419-019-1407-6. PMID: 30792387; PMCID: PMC6384907. [5] Tsujimoto Y. Cell death regulation by the Bcl-2 protein family in the mitochon...
Functional characterization of the Bcl-2 gene family in the zebrafish. Cell Death Differ. 13, 1631–1640 (2006). Article CAS PubMed Google Scholar Hengartner, M. O. & Horvitz, H. R. Activation of C. elegans cell death protein CED-9 by an amino-acid substitution in a domain conserved...
Small molecules targeting Bcl-2 family protein in clinical development Venetoclax毒副作用及药物使用 对于有应答的患者,venetoclax药效可能奇快,为防止病人出现肿瘤溶解综合征(tumor lysis syndromes),FDA获批的剂量的使用非常特殊。最终建议的使用方式是剂量递增方案,具体用量是5周内剂量从20 mg递增到400 mg。
The Bcl-2 protein family. Exp Cell Res. 2000;256:50-7.Hetz C.BCL-2 protein family. Essential regulators of cell death. Preface. Advances in Experimental Medicine and Biology . 2010Antonsson B,Martinou JC.The Bcl-2 protein family. Experimental Cell Research . 2000...
Small molecules targeting Bcl-2 family protein in clinical development Venetoclax毒副作用及药物使用 对于有应答的患者,venetoclax药效可能奇快,为防止病人出现肿瘤溶解综合征 (tumor lysis syndromes),FDA获批的剂量的使用非常特殊。最终...