Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redun- dant for their programmed death. Mol Cell Biol. 2004;24(4):1570-1581.Coultas, L., P. Bouillet, E.G. Stanley, T.C. Brodnicki, J.M. Adams, and A. Strasser. ...
Hikita H,Takehara T,Kodama T,et al.BH3-only protein bid par-ticipates in the Bcl-2 network in healthy liver cells.Hepatology. 2009Hikita H,Takehara T,Kodama T,et al.BH3-only protein bid par-ticipates in the Bcl-2 network in healthy liver cells. Hepatology . 2009...
M. Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy. Nat. Rev. Mol. Cell Biol. 15, 49–63 (2014). CAS PubMed Google Scholar Kuwana, T. et al. BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane ...
There is mounting evidence for the role of BH3-only members of the Bcl-2 family in this process. While earlier studies defined a role for PUMA and NOXA in ER stress-induced apoptosis in neuronal cells and in MEFs,7,8,9we had reported a role for BIM in lymphocytes, macrophages and epit...
摘要:Bcl-2家族蛋白质在细胞凋亡的调控机制中起着重要的作用,该家族包括唯BH3结构域的蛋白 质(onlyBH3domainprotein),如Bid、Bik、Puma、Nova、Bmf等。随着凋亡研究的深入,在哺 乳动物中现已发现10多种唯BH3结构域的蛋白质,并且在凋亡中发挥重要的作用。本文主要论述唯 ...
Puma and deficiency of this BH3-only protein can also provide protection from hepatocyte killing upon systemic TNF administration.7Together these findings show that mitochondrial apoptosis, controlled by the Bcl-2 family, can be a critical event in pathological hepatocyte cell death in response to ...
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells (1). This process is regulated by the interplay of pro- and anti-apoptotic members of the B-cell lymphoma 2 (Bcl-2) family (2). The BH3-only (Bcl-2-homology domain 3 only) ...
Protein structureB-cell lymphoma-2 (Bcl-2) homology-3 (BH3)-only proteins are considered members of the Bcl-2 family, though they bear little sequence or structural identity with the multi-BH motif prosurvival or proapoptotic Bcl-2 proteins like Bcl-2 or Bax. They are better considered a...
The mitochondrial pathway of apoptosis is initiated by Bcl-2 homology region 3 (BH3)-only members of the Bcl-2 protein family. On upregulation or activation, certain BH3-only proteins can directly bind and activate Bak and Bax to induce conformation change, oligomerization and pore formation in...
The mitochondrial pathway of apoptosis is initiated by Bcl-2 homology region 3 (BH3)-only members of the Bcl-2 protein family. On upregulation or activation, certain BH3-only proteins can directly bind and activate Bak and Bax to induce conformation change, oligomerization and pore formation ...