There is increasing interest in a subfamily of the Bcl-2 family, the BH3-only proteins, and their pro-apoptotic effects within neurons. Recently ischemic and seizure-induced neuronal injury has been shown to result in the activation of the BH3-only protein, Bid. This protein is cleaved and...
BH3-only proteins trigger apoptosis by a mechanism that requires BAX- (BCL-2-associated X protein)/BAK (BCL-2-antagonist/killer)-like members of the multi-BH-domain pro-apoptotic subgroup of the BCL-2 family. The BH3-only protein BIM (BCL-2-interacting mediator of cell death) is essenti...
While C. elegans has one homologue each of Ced-9 and Egl-1, human has 13 Ced-9 homologues (multi-region Bcl-2 proteins) and a number of highly divergent proteins that are analogous to Egl-1 (BH3-only protein). Within the Bcl-2 family, the evolutionary relationship between multi-region...
The BH3 domain folds into an α-helical bundle only upon its interaction with the hydrophobic groove of the prosurvival Bcl-2 family proteins (Rautureau et al., 2012, Sattler et al., 1997). Mutational analyses have demonstrated that the BH3 domain is required for the binding BH3-only ...
The BH3-only members of the Bcl-2 protein family are essential initiators of programmed cell death and are required for apoptosis induced by cytotoxic stimuli. These proteins have evolved to recognise distinct forms of cell stress. In response, they unleash the apoptotic cascade by inactivating th...
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only members activate the essential effectors Bax and Bak remains contro... D Mérino,M Giam,PD Hughes,... - 《...
Anti-apoptotic members of the Bcl-2 family proteins play central roles in the regulation of cell death in glioblastoma (GBM), the most malignant type of brain tumor. Despite the advances in GBM treatment, there is still an urgent need for new therapeutic approaches. Here, we report a novel...
BH3-only members of the Bcl-2 intracellular protein family, which include Bim, Bmf, Bik, Bad, Bid, Puma, Noxa and Hrk, mediate many developmentally program... SN Willis,JM Adams - 《Current Opinion in Cell Biology》 被引量: 1915发表: 2006年 The role of BH3-only proteins in the immu...
BH3-only proteins and Bax are members of Bcl-2 family,their functions are to regulate cell apoptosis. 仅含BH3区域蛋白(BH3-onlyproteins,BOPs)及Bax均属于Bcl-2蛋白家族,其功能为调整细胞凋亡,不同的仅含BH3区域蛋白受不同的机制调节。4) Maf family proteins Maf家族蛋白 1. Maf family proteins ...
Keeping killers on a tight leash: transcriptional and post-translation control of the pro-apoptotic activity of BH3-only proteins. BH3-only proteinsare structurally distant members of the Bcl2 protein family that trigger apoptosis. Genetic experiments have shown that these proteins are... Puthalakat...