BCL-2基因，即B淋巴细胞瘤-2基因，它具有明显抑制细胞凋亡的作用，也是细胞凋亡研究中最受重视的癌基因之一。BCL-2蛋白家族非常庞大，按功能可分为促凋亡蛋白和抗凋亡（促存活）蛋白，前者由BH123（含有多个BH同源区域）蛋白和BH3-only（仅含BH3结构同源域）蛋白这两个亚家族组成，后者由BCL-2以及它的近亲蛋白组...
[2] BCL-2 protein family: attractive targets for cancer therapy. Apoptosis 2023, 28, 20-38.
[1] BCL2: A Promising Cancer Therapeutic Target. Biochimica et Biophysica Acta, Reviews on Cancer 2017, 1868, 309-314. [2] BCL-2 protein family: attractive targets for cancer therapy. Apoptosis 2023, 28, 20-38. PS:关注以下腾讯文档获取网化研选每周特价产品以及最新分子砌块产品,每周更新,周周...
BCL-2最初是在t(14;18)染色体易位中发现的，这种易位发生在滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤（DLBC...
凋亡是细胞受到某种信号刺激后进行的一种程序化死亡,对于调节多细胞生物的个体发育,体内平衡具有重要作用 。过度的调亡与神经退行性疾病等有关,而调亡受到抑制则与肿瘤等疾病的产生有关。[2] 01 / Bcl-2结构与分布 图源:basic apoptosis discoveries to advanced selective BCL-2 family ...
Danial NN.BCL-2 family proteins:critical checkpoints of apoptoticcell death.Clinical Cancer Research. 2007BCL-2 family proteins:critical checkpoints of apoptoticcell death. Danial NN. Clinical Cancer Research . 2007Danial NN. BCL-2 family proteins: critical checkpoints of apoptotic cell death. Clin...
Protein stability also impacts abundance of the BCL-2 family proteins. The relative abundance and affinity ultimately determine which binding interactions dominate and whether or not the cell undergoes MOMP committing it to apoptosis Introducing the dance of death Dancing is a joy of life; however,...
M. Structure of M11L: a myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci. 16, 695–703 (2007). Article CAS PubMed PubMed Central Google Scholar Aoyagi, M. et al. Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein. Protein...
The Bcl-2 protein family. Exp Cell Res. 2000;256:50-7.B Antonsson,JC Martinou.The Bcl-2 protein family. Experimental Cell Research . 2000Antonsson B,Martinou JC.The Bcl-2 protein family. Experimental Cell Research . 2000Antonsson B, Martinou JC. The Bcl-2 protein family. Exp Cell ...
Discover how BCL-2 protein family overexpression affects apoptosis in acute myeloid leukemia (AML) patients, why the BCL-2 family functions as a vital pathway in apoptosis, the role of BCL-2 in perpetuating chemoresistance, and how the standard of care f