During apoptosis, cell fate is determined by complex protein–protein and protein–membrane interactions between the pro- and anti-apoptotic Bcl-2 family members. Commitment to apoptosis is marked by the permeabilization of the outer mitochondrial membrane, a step often considered as the point of no...
These factors result in a complex interaction network, the sum of which determines cellular fate. The first step in understanding the BCL-2 family interaction network is to establish the affinities between binding partners. The reported affinities of known BCL-2 family protein interac- tions are ...
M. Structure of M11L: a myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci. 16, 695–703 (2007). Article CAS PubMed PubMed Central Google Scholar Aoyagi, M. et al. Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein. Protein...
Structures of Bcl-xL in complex with these BH3 peptides showed that they bind as an amphipathic α-helix and make extensive hydrophobic contacts with the protein. These data have not only helped to elucidate the interactions important for hetero-dimerization of Bcl-2 family members but have ...
Discover how BCL-2 protein family overexpression affects apoptosis in acute myeloid leukemia (AML) patients, why the BCL-2 family functions as a vital pathway in apoptosis, the role of BCL-2 in perpetuating chemoresistance, and how the standard of care f
中文名称 :Bcl-2同源结构域蛋白单*抗体 别名:Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN. 研究领域 :免疫学 神经生物学 细胞凋亡 抗体来源 :Mouse ...
分子伴侣CESK1蛋白抗体 价格: 价格电议 产品详情:英文名称 Anti-CESK1中文名称分子伴侣CESK1蛋白抗体别 名 CCT8L2; KCNMB3L; T complex protein 1; CESK1; chaperonin containing... 纯度:详见说明书% 包装规格:0.2ml/200μg 用途:产品仅用于科研实验 用途:产品仅用于科研实验 货号:BJ-K3516 品牌:邦景 蛋...
FamilyReactive蛋白质类磷酰化家庭We examined the influence of ROS on the phosphorylation and complex formation of Bcl-2 family proteins in Mn-superoxide dis-mutase (SOD) antisense-transfected squamous cell carcinoma cells, OSC-4 cells. The increase of intracellular ROS level induced by cis -diam...
中文名称Bcl-2同源结构域蛋白单克隆抗体 别名Beclin-1; ATG6; beclin1; VPS30; Beclin 1 like protein 1; 4921513J16Rik; 5430417M23Rik; ATG6; BECLIN 1; BECN1; MGC6843; BECN1_HUMAN. 研究领域肿瘤 免疫学 神经生物学 细胞凋亡 抗体来源Mouse 克隆类型Monoclonal 克隆号7B12 交叉反应Human, Mouse, ...
Among these complexes, two can be considered as specific to eukaryotes—the translocases of the outer membrane (TOMs) and the members of the Bcl-2 family (Bcl-2s) complexes—respectively implicated in protein import of nuclei-encoded mitochondrial proteins and in the regulation of the ...