Objectives To explore the regulation of Bax and Bcl 2 gene on the cardiocyte apoptosis in acute myocardial infarction in rabbits. Methods Forty eight New Zealand rabbits were enrolled in the study.A randomized design was used to assign 42 rabbits in the 7 experimental groups (including 1 h ,...
[Abstract]Background and purpose:Diffuse large B-cell lymphoma/high-grade B-cell lymphoma (DLBCL/HGBL) with gene rearrangement ofMYC, BCL2 andBCL6, also known as triple-hit lymphoma (THL), has a low incidence an...
2.4.1 The Bcl-2 Family One of the most important regulators of intrinsic pathway of apoptosis is the Bcl-2 protein family [11,56]. The Bcl-2 gene was originally identified at the chromosomal breakpoint of the translocation of chromosome t(14:18) in follicular non-Hodgkin lymphoma. U...
本研究中,我们报道了40例MYC/BCL2/BCL6三打击淋巴瘤,为迄今为止最大样本量的报道,并将其与157例MYC/BCL2双打击淋巴瘤和13例MYC/BCL6双打击淋巴瘤进行了系统地对比分析,更好地描述了三打击淋巴瘤的临床病理学特征和预后。 ...
、、 、。 [] Bcl-2;Bax;; [] R734 [] A ,, 。 “”———。 、 (), , , :。 1984 Bcl- (mitochondrialpermeabilitytransitionpor,eMPT), 2 B, 20 、、 ,; (■Ym)。 , Bcl-2 ——— C。 ATP , Bcl-2 Bax , C(cytochrome,ccyto-c) ,。 Apaf-1。 CARD(caspase 。 recruitment...
CARD11,Bcl-2和NF-κB在弥漫性大B细胞淋巴瘤中的表达与意义 目的:观察弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma DLBCL)中CARD11,NF-κB和Bcl-2表达情况,探讨它们在弥漫性大B细胞淋巴瘤中不同免疫分型中表达的意义及相... 左云海 - 《南昌大学》 被引量: 3发表: 2008年 加载更多来源...
差异有统计学意义(P<0.05).结论黄芩苷通过抑制糖尿病视网膜病变大鼠细胞凋亡率,下调cleaved-Caspase-3,Bax表达,上调Bcl-2表达,进而对糖尿病视网膜病变起到改善作用... 马静,陈雨,李玉红 - 国际生物医学工程杂志 被引量: 0发表: 2024年 Possible mechanism for hepatitis B virus X gene to induce apoptosis of...
(93%) were identified correctly to species level, seven strains (6%) were incorrectly identified, and one strain (1%) remained unidentified.Significance and Impact of the Study: The VITEK2 BCL card provides a major advance in the reliable identification of Bacillus species and members of related...
M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-Myc to immortalize pre-B cells. Nature 335, 440–442 (1988).Discovery that Bcl2 promotes cell survival. First recognition that cell survival is controlled separately from cell proliferation and that inhibition of apoptosis is...
Nearly the same fold is also seen in the Bcl-2/Bax-family protein, Bid, which is usually considered a BOP rather than a MDP due to the lack of sequence similarity in BH1 and BH2.13 Physiological Roles of MDPs Gene ablation studies in mice have provided insights into the physiological ...