Earlier workers reported rearrangement of this gene (located on chromosome 18) in a major fraction of follicular lymphomas, lymphomas in which a 14;18 chromosome translocation is frequently observed. In the present study, bcl-2 was rearranged in 30% (11 of 37) of follicular lymphomas and 19%...
[Abstract]Background and purpose:Diffuse large B-cell lymphoma/high-grade B-cell lymphoma (DLBCL/HGBL) with gene rearrangement ofMYC, BCL2 andBCL6, also known as triple-hit lymphoma (THL), has a low incidence an...
A unique Ig gene rearrangement, distinct from the original tumor, was noted in a late-onset lymphoma of a doxycycline-treated mouse supporting the emergence of a clonally distinct tumor (Figure 6E). In summary, the late-onset B cell lymphomas that follow ablation of BCL-2 expression resemble ...
28. Li S, Weiss VL, Wang XJ, Desai PA, Hu S, Yin CC, Tang G, Reddy NM, Medeiros LJ, Lin P. High-grade B-cell lymphoma with MYC rearrangement and without BCL2 and BCL6 rearrangements is associated with...
另外,研究者们还观察到,与bcl-2断裂易位相似的情况还发生在其他基因位点,如t(11;14)(q13;q32)中BCLl和IgH基因的重排。这种癌基因不同,断裂机制不同,但最终都能以相似的方式与免疫球蛋白重链基因融合的现象,又引出了一种假说,即免疫球蛋白重组过程中,重组激活基因(recombinationactivatinggene,RAG)1和2引起IgH...
BCL2 was originally identified in Croce's lab in 1984 as the target within the breakpoint region of the t(14;18) translocation carried by patients with the follicular variant of B-cell lymphoma, from which it takes its name.1 Such chromosomal rearrangement places the immunoglobulin heavy-chain...
(1994). Clinical significance of bcl-2-MBR gene rearrangement and protein expression in diffuse large-cell non-Hodgkin's lymphoma: an analysis of 83 cases. J Clin Oncol 12: 149–154. Article CAS PubMed Google Scholar Thomenius MJ, Distelhorst CW . (2003). Bcl-2 on the endoplasmic ...
医学论文-弥漫性大B细胞淋巴瘤bcl作者:**勇,陈愉,张三泉,朱梅刚,赵彤【关键词】弥漫Correlationbetweenbcl2/IgHgenerearrangementandGCBmolecularsu..
In the remaining one case, the 5′‐BCL2 fused 3’of a Vλ, gene that was upstream of another Vλ/Jλ complex carrying a non‐producing configuration, indicating that the receptor editing mechanism was likely involved in this rearrangement. Our study revealed heterogeneous anatomy of the 5′...
a0 0 [translate] aRESPOND 反应 [translate] aCan play English 正在翻译,请等待... [translate] aind 开始 [translate] aALL cases with rearrangement of the MLL gene may be particularly responsive to Bcl-2 inhibition 所有案件以MLL基因的重新整理也许是特别敏感的对Bcl-2禁止 [translate] ...