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编码BCR的基因在胚系阶段以分隔的、数量众多的基因片段(gene segment)的形式存在。在B细胞的分化发育过程中,这些基因片段发生重排(rearrangement)和组合,从而产生数量巨大、能识别特异性抗原的BCR。 不同时期的BCR重排 BCR的基因重排及其机制:Ig的胚系基因是以被分隔开的基因片段的形式成簇存在的,只有通过基因重排形成V...
B cell developmentIg gene rearrangementJH locustargeted mutationB lymphocyte differentiation is characterized by an ordered series of Ig gene assembly and expression events. In the majority of normal B cells, assembly and expression of Ig heavy (H) chain genes precedes that of light (L) chain ...
编码BCR的基因在胚系阶段以分隔的、数量众多的基因片段(gene segment)的形式存在。在B细胞的分化发育过程中,这些基因片段发生重排(rearrangement)和组合,从而产生数量巨大、能识别特异性抗原的BCR。TCR和BCR的基因结构以及发生重排的机制十分相似,本节以BCR为例简述其基因结构和重排特征。 1.BCR的胚系基因结构 Ig轻链和...
1、抗体、基因重排及B细胞发育 Antibody Molecules, Their Antibody Molecules, Their Genes and B Cell Development Genes and B Cell Development 抗体分子、基因和抗体分子、基因和 B B 细胞发育细胞发育 Chapter 7Chapter 7 抗体、基因重排及B细胞发育 获得性免疫系统的获得性免疫系统的 “ “五项基本原则五项...
16. Savage KJ, et al. MYC gene rearrangements are associated with a poor prognosis in diffuse large B-cell lymphoma patients treated with R-CHOP chemotherapy. Blood. 2009 Oct 22;114(17):3533-7. 【17. Chapuy B, et al. Molecular ...
Germline stage Ig genes undergo the VDJ rearrangement, becoming hugely diversified, and can react with almost all antigens. Except for the adaptive B cells, some types of B cells are also found to be associated with innate immunity. The innate-like B cell subsets form a bridge between the ...
4. Tucci A, Re A, Pagani C, et al. Rituximab with dose-adjusted EPOCH (R-DA-EPOCH) with or without autologous stem cell transplantation (ASCT) as first line treatment in patients with aggressive B-cell lymphoma wit...
This gene rearrangement is crucial to the diversity of the B cell repertoire—enabling a large number of different specificities of Ig in order to improve chances of antigen recognition. It may also be the case that a more diverse response is more effective than a high affinity oligoclonal ...
The B- and T-cell gene rearrangement test detects monoclonal populations of lymphocytes and distinguishes benign from neoplastic conditions. Deoxyribonucleic acid probes to the genes encoding a T-cell receptor and immunoglobulin heavy and light chains assess the clonality of certain conditions. The test...