Bcl-xL蛋白与肿瘤 Ｂｃｌ—ｘＬ蛋白与肿瘤 刘建杨建明 赵俊 星璧瞪鬓塑查；塑！兰篓丝堂箜！！塑！蹩！塞塑￡ｉ！：墅￡：；！她：塑！：！！：签！：！！【摘要】蠲它怒机体去除多余的或者潜在有害的缃胞，达羁自我警褥的一种机制。蠲亡不足是很多疾瘸的基础，包括肿瘤。研究显示Ｂｃｌ—ｘＬ基因及...
X has two isoforms, Bcl-XL (long), a 241 amino acid protein which suppresses cell death. And Bcl-XS (short), a 178 amino acid protein lacking a 63 amino acid domain which functions as a dominant inhibitor of Bcl-2. This monoclonal antibody reacts with both Bcl-XS and Bcl-XL ...
(D) CD83, BCL2A1, BCL2, MCL1 and BCLXL gene expression in BCL2A1 positive MCL cell lines (SP53, NTS3, REC-1, Mino) treated for 24 hours with ibrutinib (500 nM) was evaluated by bulk RNA-sequencing. ANOVA test; ∗∗P < .01, ∗P < .05. (E) Synergy score (highest ...
Bcl-xL Bid Bim Bmf Bok Boo CARD caspase-1 (mouse) caspase -2 (mouse) caspase-11 (mouse) caspase-12 (mouse) caspase-1 caspase-2 caspase-3 caspase-4 caspase-5 caspase-6 caspase-7 caspase-8 caspase-9 caspase-10 Cdk4 Diablo/Smac E2f1 endonuclease G ...
BOPs can be classified as type I proteins that function as antagonists of anti-apoptotic proteins such as Bcl-2 and Bcl-XL, and type II proteins that function both as antagonists of antiapoptotic Bcl-2-family proteins and as agonists of proapoptotic MDPs. Studies using genetically engineered ...
Independently, the genetic data strongly argue that the level of XL and L isoforms is influenced by sequence variants in the BCL11A gene. BCL11A Binds the NuRD Repressor Complex, GATA-1, and FOG-1 in Erythroid Cells To better understand the mechanism of action of BCL11A in erythroid cells,...
ELISA test and Quantitative real-time PCR assay was performed to determine the role of caspase-3, Bak, Bax, Bcl-2, Bcl-xL and Mcl-1 proteins in the inhibition of cell proliferation triggered by the tested agents. RESULTS We found that aggressive MDA-MB-231 cell line was more sensitive ...
EST clone IMAGE:703916, containing the ORF of BCL10 gene was purchased form Invitrogen (Carlsbad, CA) and utilized as template for construction of all the BCL10-derived expression vectors. Expression vectors pCMV6/XL5/MALT1 (containing full length MALT1 cDNA) and pCMV6/XL5/IAP2 (Containing ...
(Bcl-XLBax Bc2lBax)≥50%, ; Bax80%, 。, Bcl-2 , ; Bcl-2 Bax“”(rheo- stat), , Bc-2 Bax。、、 、。 [] Bcl-2;Bax;; [] R734 [] A ,, 。 “”———。 、 (), , , :。 1984 Bcl- (mitochondrialpermeabilitytransitionpor,eMPT), 2 B, 20 、、 ,; (■Ym)。 , Bcl-...
This impacted the levels of short- lived proteins like MCL1 and BCL-XL, but not of BCL2 (Fig. 6a,b). There was also a simultaneous increase in amounts of the pro-apoptotic BAK in OCI-Ly13.2 (Fig. 6a,b). Overall, these THZ1-induced changes caused a shifted BH3 profiling (Fig. ...