CARD11,Bcl-2和NF-κB在弥漫性大B细胞淋巴瘤中的表达与意义 目的:观察弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma DLBCL)中CARD11,NF-κB和Bcl-2表达情况,探讨它们在弥漫性大B细胞淋巴瘤中不同免疫分型中表达的意义及相... 左云海 - 《南昌大学》 被引量: 3发表: 2008年 加载更多来源...
:bcl-X, abcl-2-related gene that functions as a dominant regulator of apoptotic cell death.Cell 74: 597–608, 1993. Article Google Scholar Oltvai ZN, Milliman CL, Koŕsmeyer SJ: Bcl-2 heterodimerizesin vivo with a conserved homolog, Bax, that accelerates programmed cell death.Cell 74:...
[关键词]弥漫性大B细胞淋巴瘤/高级别B细胞淋巴瘤;三重打击淋巴瘤;基因重排;临床病理学特征;免疫表型;生存 [Abstract]Background and purpose:Diffuse large B-cell lymphoma/high-grade B-cell lymphoma (DLBCL/HGBL) with gene ...
Apaf-1。 CARD(caspase 。 recruitmentdomain) Caspase-9 , Caspase-9 。 1 C、Apaf-1 Caspase-9 (holoenzyme) “”(apoptosome)。 Caspase- , 9 Caspase-3 。 C, 。 , : (apoptosis-in- :。 ducingfacto,rAIF) Caspase-3 。 MPT (deathrecepto,rDR) : adeninenucleo- ,, tidetranslocator(ANT);...
Possible mechanism for hepatitis B virus X gene to induce apoptosis of hepatocytes CONCLUSION: HBV X gene may promote the apoptosis of hepatocytes by regulating the expressions of Fas/FasL, Bax/Bcl-2, and c-myc gene in a dose-... Sheng-Jun,Zhang,Hong-Ying,... - 《World Journal of Gast...
伴MYC、BCL2和BCL6重排(三打击)的高级别B细胞淋巴瘤并不常见。我们研究了40例三打击淋巴瘤患者的临床病理特征,并将其与157例MYC/BCL2双打击淋巴瘤患者和13例MYC/BCL6双打击淋巴瘤患者进行比较。三打击淋巴瘤患者为25名男性和...
湿疣中的表 ［摘要］目的：测定ｓｕｒｖｉｖｉｎ和Ｂｃｌ一２在尖锐湿疣（ＣＡ）组织中的表达并探讨两者表达的关系。方法：应用免疫组织化学链霉菌抗生物素蛋白过氧化物酶方法（ｓＰ法）分别检测６０例ＣＡ组织及１０例正常包皮组织中ｓｕｒｖｉｖｉｎ、Ｂｃｌ一２基因的表达。在镜下观察切片并计算阳性细胞百分比。结...
Cardiou, H.L.A. Vieira, N. Zamzami, I. Marzo, Z. Xie, B. Leber, D. Andrews, H. Duclohier, J.C. Reed, and G. Kroemer. 2000. Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Oncogene. 19:329-336....
Nearly the same fold is also seen in the Bcl-2/Bax-family protein, Bid, which is usually considered a BOP rather than a MDP due to the lack of sequence similarity in BH1 and BH2.13 Physiological Roles of MDPs Gene ablation studies in mice have provided insights into the physiological ...
However, a novel drug class targeting pro-survival Bcl-2 protein family members has been developed with the understanding of the structures and interactions of Bcl-2 proteins. Within this new class, Bcl-2/Bcl-xL inhibitor Navitoclax and Bcl-2 specific inhibitor Venetoclax have been shown to ...