Empty CellRAW264.7 macrophage cell linesiRNA mediated knockdown of CHOP attenuated atherogenic lipid-mediated induction of proteins and genes implicated in macrophage mediated inflammation, ER stress (ATF4 and ATF6), and apoptosis (CHOP).Zahid et al.65 ...
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol. 2011;29:341. Article CAS PubMed Google Scholar Pardridge WM. Intravenous, non-viral RNAi gene therapy of brain cancer. Expert Opin Biol Ther. 2004;4(7):1103–13. Article CAS PubMed Google ...
a, b. Dynamic analysis of pre-rRNA synthesis and processing by metabolic pulse-chase labeling. Cells treated for 3 days with an siRNA targeting DDB1 a, or ZNF622 b, or with a non-targeting SCR siRNA control were labeled with tritiated methionine for 30 min and the label was then “chase...
siRNA-based therapy has s... C Huang,M Li,C Chen,... - 《Expert Opin Ther Targets》 被引量: 207发表: 2008年 Promising new developments in cancer chemotherapy The positive impact on survival of traditional chemotherapeutic agents has renewed interest in developing newer cytotoxic agents and ...
In an in vivo orthotopic mouse model of ovarian cancer, ALDH1A1 silencing using nanoliposomal siRNA sensitized both taxane- and platinum-resistant cell lines to chemotherapy, significantly reducing tumor growth in mice,compared to chemotherapy alone. These data demonstrate that the ALDH1A1 ...
(1840). 2014 Diatomite biosilica nanocarriers for siRNA transport inside cancer cells. Biochimica et Biophysica Acta (BBA)-General Subjects, 12, 3393–3403. Google Scholar Banihashem, S., Nezhati, M. N., & Panahia, H. A. (2020). Synthesis of chitosan-grafted-poly (N-vinylcaprolactam) ...
In an in vivo orthotopic mouse model of ovarian cancer, ALDH1A1 silencing using nanoliposomal siRNA sensitized both taxane- and platinum-resistant cell lines to chemotherapy, significantly reducing tumor growth in mice,compared to chemotherapy alone. These data demonstrate that the ALDH1A1 ...
HO-1 and CO did not protect STAT3 siRNA-treated murine lung endothelial cells or endothelial-specific STAT3-deficient mice against hyperoxic injury. However, STAT3 overexpression partially reduced cell apoptosis induced by hyperoxia in HO-1-deficient murine lung endothelial cells (Lee et al., 1996)...
The clinical applications of inhaled siRNA formulations still face challenges because effective delivery of siRNA to the lung requires overcoming the pulmonary and cellular barriers. This paper reviews the research progress for siRNA inhalation formulations for the treatment of various respiratory diseases ...
The clinical applications of inhaled siRNA formula- tions still face challenges because effective delivery of siRNA to the lung requires overcoming the pulmonary and cellular barriers. This paper reviews the research progress for siRNA inhalation formulations for the treatment of various respiratory ...