aThe weak mutation in SHL2 (ROL) provides a unique opportunity to examine the regulation of polarity of lateral organs by genes in the ta-siRNA pathway during the reproductive phase in rice. Using this mutant, we found that stamen development is under the unique regulation of adaxial-abaxial ...
aFor design siRNA targeting u-PA, a DNA sequence of the type AA(N19) was selected. 正在翻译,请等待...[translate] acoverstitch coverstitch[translate] aI can manage it myself. 我可以处理它我自己。[translate] aThe initiative for a long time will be very tired, care about for a long ti...
The pharmacological effect of the drug molecules can be compared to the effect of genetic alteration of the target using siRNA knockdown or CRISPR gene editing11,12. However, validation of drug target is still challenging since drug's pharmacological effect (efficacy and toxicity) may be resulted ...
CONTROLLING RNA Using small oligonucleotides, such as endogenous (miRNA) (Fabian et al., 2010), synthetic RNA (shRNA, siRNA), or other nucleic acid analogs (locked nucleic acids LNA, morpholino, 2′- O-methyl RNA oligo) (Cooper et al., 2009), it is possible to block gene ...
a siRNA drug that treats hereditary transthyretin-mediated amyloidosis, a neurodegenerative disease caused by a defective gene. Patisiran is encapsulated in an LNP to protect it until it reaches the liver, where it then prevents expression of the defective gene. Patisiran was approved in the United...
vehicles suited for mRNA delivery, the mRNA field is currently strongly capitalizing on the vast knowledge gained during the clinical development of small interfering RNAs (siRNA). Efficient systemic delivery of siRNA can be achieved by its encapsulation into so called LNPs, with the first RNAi LNP...
a‘Good design is not inevitable. It needs to be championed’ `好设计不是不可避免的。 它需要拥护’[translate] awe mustnotburnhercake. 正在翻译,请等待...[translate] aSystem.Data.OleDb.OleDbException: Syntax error (missing operator) in query expression ''[translate] ...
(qualitative information) had been placed on the studyHuman Immuno Deficiency Virusdata.The education activity appeared to be a proper and appropriate for CPD and ended up being seen to be concise and exposed tips in a rational and succinct fashion aided by the potential to profit the ...
aWe hypothesized that BLM may perform a reciprocal function to WRN, in that BLM may be restricted to suppressing G-SCE, but WRN involvement is in suppressing T-SCE. However, siRNA knockdown of BLM in normal human fibroblasts (telomerase-negative) demonstrated a role for BLM in suppressing both...
我们在细胞增殖、细胞周期、apoptosis和invasiveness transfected TPX2-siRNA入海拉细胞学习TPX2 downregulation的作用。 我们发现TPX2的downregulation使用TPX2-siRNA禁止了子宫颈癌海拉细胞的扩散和invasiveness。 禁止TPX2表示由RNAi增加了S阶段和G2阶段细胞和细胞apoptosis的百分比。 我们观察细胞ap[translate] ...