Exosome-mediated delivery of siRNA in vitro and in vivo. The use of small interfering RNAs (siRNAs) to induce gene silencing has opened a new avenue in drug discovery. However, their therapeutic potential is hamp... S El-Andaloussi,Y Lee,S Lakhal-Littleton,... - 《Nature Protocols》 被引...
How to Tackle the Challenge of siRNA Delivery with Sequence-Defined Oligoamino Amidesdoi:10.1002/mabi.201600152Sren ReinhardErnst WagnerJohn Wiley & Sons, LtdReinhard, S., and Wagner, E. (2017) How to Tackle the Challenge of siRNA Delivery with Sequence-Defined Oligoamino Amides. Macromol. Bio...
aThe cognate sequence of an siRNA is either located on the untranslated 5′region of an mRNA, the open reading frame, or the 3′end of the message. siRNA的同源序列位于mRNA、开放读书框架或者消息的3 ′末端的未翻译的5 ′区域。[translate] ...
Sequence-independent self-assembly of germ granule mRNAs into homotypic clusters. Mol. Cell 78, 941–950.e12 (2020). This study reveals that germ granules organize their mRNAs into distinct clusters through a self-sorting mechanism inherent to the mRNA. Article CAS PubMed PubMed Central Google ...
Tumor suppressor genes regulate the cell cycle negatively. Tumor suppressor genes are DNA sequences that encode proteins that can halt progression of...Become a member and unlock all Study Answers Start today. Try it now Create an account Ask a question Our experts can answer your tough ...
RNA polymerases initiate transcription at specific DNA sequences called promoters, where they unwind the double-stranded DNA so that one strand can be used as a template for the synthesis of a chain of ribonucleotides complementary in base sequence. RNA polymerase...
Obviously their genomes would be flexible enough to include short late domain sequences to recruit ESCRTs. In the absence of ESCRTs, one or several factors, viral or yet unknown cellular factors, may set the stage for membrane fission. In case of influenza virus, the mechanism of hydrophobic...
In light of these, NP-based siRNA delivery systems can be a promising approach to silence the SARS-CoV-2 genome targets to halt the infection. 2.1.3. Neutralizing antibodies (nAbs) In addition to what has been mentioned, the other important target for developing antivirals against SARS-CoV-...
aFor design siRNA targeting u-PA, a DNA sequence of the type AA(N19) was selected. 正在翻译,请等待... [translate] acoverstitch coverstitch [translate] aI can manage it myself. 我可以处理它我自己。 [translate] aThe initiative for a long time will be very tired, care about for a ...
A. What does it mean to 'knock-out' a gene? B. How would the process of knocking out a gene aid in determining a function of the gene? How has gene duplication played a critical role in evolution? Can gene flow cause changes in DNA sequences?