Bacterial extracellular vesicles (BEVs) enable communication between bacteria and their natural habitats, including multicellular organisms such as humans. Consequently, the study of BEVs has rapidly gained attention with recent research raising the prospect of developing BEVs as biomarkers and treatments ...
we performed additional experiments using extracellular vesicles of different condition (see Supplementary Methods for details). First, to examine whether the protein components of extracellular vesicles were the actual inducers of IFN-γ, we boiled both theE. coli ∆msbBOMVs andS. aureus...
Herein, we fabricate a versatile nanosystem for efficient tumor immunotherapy by synergizing the efferocytosis blockade-induced secondary necrosis with the bacterial outer membrane vesicles (OMVs)-based antigen transfer and immune augment. One of the small-molecule MerTK inhibitors UNC2025 is loaded into ...
Studies conducted so far with various bacterial infection models demonstrate the release of various types of vesicles that include exosomes and microvesicles. Depending upon the infection and nature of cell type, vesicle composition changes and ultimately might impact the host immune response and ...
Bacterial membrane vesicles transport their DNA cargo into host cells Bacterial outer membrane vesicles (OMVs) are extracellular sacs containing biologically active products, such as proteins, cell wall components and toxins. OMVs are reported to contain DNA, however, little is known about the nature ...
Their strategy involves the use of extracellular death factors or EDFs (group of pentapeptides) secreted by bacteria (Engelberg et al., 2005; Kumar & Engelberg, 2014). Another conceivable approach is to repress the transcription of TA genes, interrupting the constant availability of the less ...
Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis Disseminated intravascular coagulation (DIC) is a complication of sepsis currently lacking effective therapeutic options. Excessive inflammatory responses...
利福昔明: 一种Bacterial RNAP抑制剂药物,目前全球最高研发状态为批准上市,作用机制: Bacterial RNAP抑制剂(细菌RNA聚合酶抑制剂),治疗领域: 神经系统疾病,消化系统疾病,内分泌与代谢疾病,在研适应症: 腹泻型肠易激综合征,旅行者腹泻,腹泻,在研机构: Bausch Health Ame
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