T细胞耗竭（T cell exhaustion）是在慢性感染和#肿瘤#发生中，T细胞自我更新减弱，细胞因子分泌减少，二次响应能力不足和高表达免疫抑制性受体（Inhibitory Receptor）的生物学过程，也是T细胞相关免疫疗法所面临的核心挑战之一。近些年来多篇报道揭示，TCF-1高表达的耗竭性T细胞的前体细胞（TCF-1hi exhausted T cell pro...
The differentiation of regulatory T (Treg) cells is strictly controlled by T cell receptor (TCR) signals. However, the downstream regulators of this process are incompletely understood. Here we have found that Bach2 blocks the genomic binding of the TCR-induced transcription factor IRF4, ...
through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). BACH2_HUMAN,Q9BY...
4.TH17 细胞与其他 CD4+ T 细胞的染色质特征 TH17 细胞与其他 T 细胞亚群之间的关系尚未得到充分的探索。为了更全面地了解 TH17 细胞的可塑性,研究比较了体外衍生的 npTH17、pTH17、TH1、Treg 细胞和无细胞因子分化的活化 T 细胞 (TH0) 之间的 ATAC-seq 和 RNA-seq。 CD4+ T 细胞亚群之间的染色质可及性...
2021年5月11日,Cell Reports在线发表了上海交通大学医学院上海市免疫学研究所黄传新课题组的研究论文,论文题目为“Bach2 attenuates IL-2R signaling to control Treg homeostasis andTfr development”。该研究发现在Treg中,转录因子Bach2能...
2016年6月24日讯 在受到感染或其他免疫反应过程中,天然的CD8 T细胞会进行快速的克隆增殖与分化,从而产生大量针对病原相关抗原的效应细胞。在抗感染免疫结束之后,大部分效应细胞会被清除,从而确保体内的免疫系统的稳态。然而,一部分细胞能够脱离被清除的命运,成为记忆细胞。记忆细胞的数量越多,在后续感染过程中的免疫反应...
BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers. T cell antigen receptor (TCR) signaling drives distinct responses depending on the differentiation state and context of CD8(+) T cells. We hypothesized that access of signal-dependent transcription ...
through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). BACH2_HUMAN,Q9BY...
When Bach2 was overexpressed, the percentage of CD4+CD25+CD45RA-T cells SLE patients expressing inflammatory factor IL-17 decreased significantly (P0.032) and the IL-17concentration in cell culture supernatants markedly decreased (P0.008). Conclusion · The of Bach2 in CD4+CD25+CD45RA-T cells...
Nature ImmunologyTom, Sidwell,Axel,etc.Bach2 is required for B cell and T cell memory differentiation.[J].2016.Sidwell T, Kallies A. Bach2 is required for B cell and T cell memory differentiation. Nat Immunol. 2016;17(7):744-5.