2022年7月5日,Cell Reports在线发表了上海交通大学医学院上海市免疫学研究所黄传新课题组的研究论文,论文题目为“Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B-cell response”。该研究发现在...
Bach2 ⋅ B cells ⋅ helper T (Th) cell ⋅ IgG ⋅ SLET and B cells participate in the development of systemic lupus erythematosus (SLE). BTB and CNC homology 2 (Bach2) is an irreplaceable regulator in the T and B lineages that helps to maintain immune homeostasi...
Two transcription factors, Pax5 and Blimp1, are responsible for the development and maintenance of B‐cell and plasma‐cell identity, respectively. Both factors regulate mutually exclusive transcriptional programs and are part of a gene‐regulatory network that ensures each other9s repression. ...
In addition to its role as a B cell-specific regulator, Bach2 acts in a cell-autonomous manner to stabilize Foxp3+Treg cells. Indeed, we observed that the proportion of Treg cells among CD4+T cells was significantly reduced in Bach2-deficient mice. To determine whether the lupus-inducing a...
Nature ImmunologyTom, Sidwell,Axel,etc.Bach2 is required for B cell and T cell memory differentiation.[J].2016.Sidwell T, Kallies A. Bach2 is required for B cell and T cell memory differentiation. Nat Immunol. 2016;17(7):744-5.
在B细胞中,BACH2对于体细胞超突变以及类别转换等事件十分重要。缺失BACH2之后会导致类别转换抗体生成受损。与AP-1家族相似,BACH2也具有一个亮氨酸拉链结构,能够与MARE顺式调控元件结合并嵌入TRE序列中。此前体外研究发现,如果将激活后的CD8 T细胞中的BACH2基因沉默,将会导致细胞难以维持。以上结果表明BACH2可能参与...
Vijay K. Kuchroo--Broad Institute of MIT and Harvard--Klarman Cell Observatory 研究简介 研究背景 平衡促炎和调节性 CD4+ 辅助 T 细胞亚群的重要性:既可以抵抗病原体和肿瘤,还能避免不受控制的炎症和自身免疫。 TH17 细胞的双重角色:TH17 细胞通过产生 IL-17 在宿主防御细胞外病原体和维持粘膜屏障稳态中起...
through repression of the antiapoptotic factor HMOX1 (PubMed:17018862). Positively regulates the nuclear import of actin (By similarity). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). BACH2_HUMAN,Q9BY...
roles in coordinating transcription activation and repression by MAFK,similarity: Belongs to the bZIP family CNC subfamily,similarity: Contains 1 BTB (POZ) domain,similarity: Contains 1 bZIP domain,subunit: Heterodimer of BACH2 and Maf-related transcription factors,tissue specificity: B-cell specific ...
黄传新研究员目前担任上海市免疫学研究所课题组长,长期致力于淋巴细胞发育与恶变的转录和表观遗传学机制的研究,为阐明自身免疫性疾病和B细胞淋巴瘤的发病机制提供新的理论根据及治疗靶点。最近几年,在国际学术刊物如Nat Commun, Cell Res, ...