2022年7月5日,Cell Reports在线发表了上海交通大学医学院上海市免疫学研究所黄传新课题组的研究论文,论文题目为“Diverging regulation of Bach2 protein and RNA expression determine cell fate in early B-cell response”。该研究发现在...
B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. Blood 2003; 102: 3317-3322.Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, Ikebe D, Igarashi K, Ito E. B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of...
In addition to its role as a B cell-specific regulator, Bach2 acts in a cell-autonomous manner to stabilize Foxp3+Treg cells. Indeed, we observed that the proportion of Treg cells among CD4+T cells was significantly reduced in Bach2-deficient mice. To determine whether the lupus-inducing a...
Two transcription factors, Pax5 and Blimp1, are responsible for the development and maintenance of B‐cell and plasma‐cell identity, respectively. Both factors regulate mutually exclusive transcriptional programs and are part of a gene‐regulatory network that ensures each other9s repression. ...
Transcriptome analyses revealed that Bach2 regulated the expression of genes related to germinal center formation and SLE pathogenesis in B cells. B cell-specific deletion of Bach2 was sufficient to impair the development of germinal center B cells but insufficient to promote the production of IgG ...
Two transcription factors, Pax5 and Blimp-1, form a gene regulatory network (GRN) with a double-negative loop, which defines either B-cell (Pax5 high) or plasma cell (Blimp-1 high) status as a binary switch. However, it is unclear how this B-cell GRN registers class switch DNA recombin...
The role of the repressors Bach1 and Bach2 in early B cell development is unclear. Igarashi and colleagues have now found these Bach factors directly repress various myeloid genes in common lymphoid progenitors to restrict a B cell lineage fate. Mature l
在B细胞中,BACH2对于体细胞超突变以及类别转换等事件十分重要。缺失BACH2之后会导致类别转换抗体生成受损。与AP-1家族相似,BACH2也具有一个亮氨酸拉链结构,能够与MARE顺式调控元件结合并嵌入TRE序列中。此前体外研究发现,如果将激活后的CD8 T细胞中的BACH2基因沉默,将会导致细胞难以维持。以上结果表明BACH2可能参与...
Bach2 was initially discovered in B cells, where it was revealed to control the transcription involved in cell differentiation. Bach2 is intimately connected to CD8 + T lymphocytes in various differentiation states and subsets according to recent findings. Bach2 can regulate primitive T cells,...
Vijay K. Kuchroo--Broad Institute of MIT and Harvard--Klarman Cell Observatory 研究简介 研究背景 平衡促炎和调节性 CD4+ 辅助 T 细胞亚群的重要性:既可以抵抗病原体和肿瘤,还能避免不受控制的炎症和自身免疫。 TH17 细胞的双重角色:TH17 细胞通过产生IL-17在宿主防御细胞外病原体和维持粘膜屏障稳态中起关键...