the majority of studies with lupus-prone mice and SLE patients indicate that T cell-dependent Ab responses are the main drivers of the disease. The initial interaction of antigen-engaged B cells with cognate CD4+T cells at the border of the T cell zone and the follicle drives B...
Cell SurvivalGene Expression Regulation, LeukemicThe B cell-specific transcription factor BACH2 is required for affinity maturation of B cells. Here we show that Bach2-mediated activation of p53 is required for stringent elimination of pre-B cells that failed to productively rearrange immunoglobulin ...
BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B lymphocytes. A picture is emerging that BACH2 may function as a master regulator of cell fate that is exquisitely sensitive to...