There was no correlation between B7H3 expression and expression of PD-L1 or PD-1 in tumor cells. Conclusions: This is the most comprehensive analysis of B7H3 expression in sarcoma to date. This data shows high levels of B7H3 expression across sarcoma subtypes, suggesting its feasibility as a...
B7-H3 expression was quantified by RNA sequencing and by IHC on pediatric PDX microarrays. We tested the safety and efficacy of m276-SL-PBD in two stages. Randomized trials of m276-SL-PBD of 0.5 mg/kg on days 1...
根据一个实施方案,本发明涉及根据本发明的抗体或抗原结合片段,其中所述癌细胞和/或转移瘤是前列腺癌、结缔组织增生性小圆细胞肿瘤、卵巢癌、胃癌、胰腺癌、肝癌、肾癌、乳癌、非小细胞肺癌、黑色素瘤、腺泡状横纹肌肉瘤(alveolar rhabdomyosarcoma)、胚胎性横纹肌肉瘤、尤因肉瘤(ewing sarcoma)、威尔姆斯瘤(wilms tumor)...
attractive target for antibody-based immunotherapy: it is overexpressed on differentiated malignant cells and cancer initiating cells, with limited heterogeneity, and high frequency (60% of 25,000 tumor samples) in many different cancer types, but has a limited expression at low level in normal ...
This review summarized the studies on B7-H3 in bone cancers. 4 studies investigated B7-H3 expression in osteosarcoma, but there is no study on B7-H3 expression in chondrosarcoma. Two studies investigated the possibility to treat Ewing`s sarcoma through targeting the B7-H3 CAR (chimeric antigen ...
2139 Introduction: MoAb 8H9 specific for cell surface glycoprotein gp58 (Cancer Res 61:4048, 2001) is broadly reactive with human solid tumors, while restricted in its expression in normal tissues. The phase I study of intra-Ommaya 131 I... H Xu,I Cheung,NK Cheung - 《Cancer Research》...
This review summarized the studies on B7-H3 in bone cancers. 4 studies investigated B7-H3 expression in osteosarcoma, but there is no study on B7-H3 expression in chondrosarcoma. Two studies investigated the possibility to treat Ewing`s sarcoma through targeting the B7-H3 CAR (chimeric antigen ...
共刺激分子B7-H3在骨肉瘤组织中的表达及临床意义
First, we have determined that 2Ig is dominant in glioma with high malignancy, and 4Ig is widely expressed, whereas 3Ig shows negative expression in all glioma. Next, we have further found that RNA binding protein annexin A2 (ANXA2) is essential for B7-H3 isoform maintenance, but fail to...
Identifying the mechanisms underlying the regulation of immune checkpoint molecules and the therapeutic impact of targeting them in cancer is critical. Here we show that high expression of the immune checkpoint B7-H3 (CD276) and high mTORC1 activity corr