All B-lineage cell lines, except for the HT line, were more susceptible than the other cell types, regardless of the expression of differentiation markers. Empty liposomes did not suppress cell proliferation. These results suggest that progesterone encapsulated in liposomes efficiently inhibits the ...
并且第一种和第三种 B cell lineage 在接种后数量变多。 说明:通过pre-F stability来提高pre-F在 F 蛋白中占比的疫苗,能成功地使B cell 向目标方向进化。不用像[1] HIV那样,在B cell maturation 的过程中输入相对应的高亲和力抗原,在RSV这个case里,只需给机体提供最终的目标抗原 pre-F,机体就能进化出针对...
and Delta on B-lineage cells and/or Notch/Jagged-1 interactions between B-lineage cells and BM stromal cells may regulate human B cell development.doi... FE Bertrand,CE Eckfeldt,AS Lysholm,... - 《Leukemia》 被引量: 166发表: 2000年 Global changes in the nuclear positioning of genes and...
Single cell deposition of 3,872 CD34+/Lin−/CD38− cells onto AFT024 with IL-7, FL, KL, IL-2, and IL-3 showed that a one time addition of IL-3 at culture initiation was essential for multilineage differentiation from single cells. Single and double lineage progeny were frequently ...
Notch-1 mRNA and protein is expressed throughout normal B cell development and in leukemic B-lineage cells. In contrast, Notch-2 expression is limited to pre-B cells expressing low levels of surface μ. The Notch ligand Delta is expressed in BM B-lineage cells. The Notch ligand Jagged-1 ...
Berglöf A, Sandstedt K, Feinstein R, Bölske G, Smith CIE (1996) B cell deficient μMT mice as an experimental model for Mycoplasma infections in X-linked agammaglobulinemia. Eur J Immunol 27:2118 Google Scholar Björkander J, Cunningham-Rundles C, Lundin P, Olsson R, Söderstr...
4-OHT-mediated deletion of Foxm1 did not significantly alter the viability of normal B-cell precursors (Fig. 1d,e, respectively) and is therefore not required for survival of IL-7-dependent pro/pre-B cells. Next we sought to analyse a potential role of Foxm1 in vivo during normal B-...
In spite of the sequential appearance of mu+ pre-B cells in fetal liver, spleen, and bone marrow, their sIgM+ B cell progeny appeared in all these hemopoietic tissues on day 17 of gestation. In the liver, sIgM+ B cells reached their peak at birth and declined thereafter. In the ...
We examined a role of p53 in early B cell development using fetal liver (FL) cells from p53 deficient (-/-) mice. Expression of p53 was detected in early B lineage (pre-B) cells developed in the stromal cell-dependent FL cell culture. Proliferation of the pre-B cells from the p53(-...
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