发现:免疫前有只结合pre-F、只结合post-F和 同时结合pre-F及post-F 的B cell,但使用稳定型 pre-F作为疫苗接种一针后,就只留下第一种和第三种 B cell,只结合post-F的 B cell就被淘汰了。并且第一种和第三种 B cell lineage 在接种后数量变多。 说明:通过pre-F stability来提高pre-F在 F 蛋白中占...
cell maturationB cells are fundamentally important cells in immune responses and the production of immunoglobulins. They have a complex developmental pathway and have a unique gene rearrangement capability providing a wide repertoire of antigen recognition that encompasees most possible epitope combinations ...
[2]Aribi, M. (2020). Introductory Chapter: B-Cells. IntechOpen. doi: 10.5772/intechopen.90636 [3]Hobeika E, Thiemann S, Storch B, Jumaa H, Nielsen PJ, Pelanda R, Reth M. Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A. 2006 Sep 12...
2024年2月26日,EMBO Mol Med发表了来自中国的华中科技大学同济医学院附属同济医院题为“B cell lineage reconstitution underlies CAR-T cell therapeutic efficacy in patients with refractory myasthenia gravis”的研究论文,报告了该研究中...
Post-translational control of B lineage commitment PAX5 controls the gene regulatory circuit that leads to B cell lineage commitment. A detailed study shows that the stability of PAX5 protein is reduced by acetylation, and that SIRT7-dependent deacetylation is required for full PAX5 activity. ...
These receptors are often expressed by immune cells in the B-cell lineage. The binding of BAFF or APRIL to their receptors supports B cells differentiation and proliferation, immunoglobulin production and the upregulation of B cell-effector molecules expression. It is possible that the overexpression...
B-lymphoblastic leukaemia/lymphoma (B-ALL/LBL) with hyperdiploidy is a neoplasm of lymphoblasts committed to the B-cell lineage whose blasts contain > 50 chromosomes (usually <66), typically without translocations or other structural a...
(both in GLA-SE), to evaluate whether immunization could initiate the CH103 bnAb B cell lineage (Fig.7a, b, Supplementary Fig.9). Relative to control-immunized (saline-injected) mice and adjuvant-only immunized (GLA-SE administered) mice, detectable differential-binding IgG+memory B cell ...
The LY-1 B Cell Lineage AM Stall,LA Herzenberg,PA Lalor,... - 《Juntendo Medical Journal》 被引量: 0发表: 1986年 Ly-1 B (B-1) cells are the main source of B cell-derived interleukin 10. We have previously reported (O'Garra, A. et al., Int. Immunol. 1990. 2: 821) that mu...
近日,澳大利亚沃尔特和伊丽莎·霍尔医学研究所Philip Hodgkin团队在Immunity上在线发表了题为Lineage tracing reveals B cell antibody class switching is stochastic, cell-autonomous, and tuneable的研究论文,利用系谱追踪、单细胞分析和数学模型,探索ASC和CSR 命运多样性的克隆起源。