Surface markers, heavy chain sequences and B cell lineages. International Review in Immunology, 8: 235-246.Wortis HH. Surface markers, heavy chain sequences and B cell lineages. Int Rev Immunol 1992;8:235-46.Wortis HH (1992). Surface markers, heavy chain sequences and B cell lineages. ...
In the past 15 years, B cells have been rediscovered to be not merely bystanders but rather active participants in autoimmune aetiology. This has been fuelled in part by the clinical success of B cell depletion therapies (BCDTs). Originally conceived as
B cell development and markers B cell development in specific organs and niche environments is coordinated by expression of transcription factors [2, 3, 4, 5, 6, 7]. Each cell fate depends on the activation and silencing of certain B cell genes and this developmental state can...
a 220 kDa surface molecule. CD45R/B220 epitope is mainly expressed by the B cell lineage from early Pro-B to mature B cells. However, some activated T cells, lymphokine activated killer cells (LAK), NK cell progenitors in the bone marrow, and T cells of the lpr/lpr mutant mouse also...
B-cells begin as a group of cells originating from stem cells designated as pro- or pre-B cells. The maturation process leading to a B cell is complex and not fully understood. What is clear is that various gene regions that control the B-cell's main product, immunoglobulins, are not ...
The success of B cell-depleting therapy in patients with multiple sclerosis and CNS diseases with an autoantibody component, such as neuromyelitis optica spectrum disorder and autoimmune encephalitides, has underscored the role of B cells in both cellular and humoral-mediated CNS conditions. Emerging ...
Successive B cell developmental stages are thus defined according to surface markers and Ig gene rearrangement status and are summarized in Table 1. In the pro-B stage, cells rearrange their Ig heavy chain genes. This is followed by surface Ig heavy chain expression with surrogate light chain, ...
The signaling capability of the pre-B cell receptor depends on its further association with Igα and Igβ, two invariant accessory chains that also attend the mature B-cell receptor. Nevertheless, they still carry markers of immaturity and are thus known as transitional T2 cells (IgM+, IgD+,...
近日,在《Science》发表了一篇题为"Vitamin A resolves lineage plasticity to orchestrate stem cell lineage choices"的研究论文。 该研究表明维生素A是调节谱系可塑性的关键调节因子。即通过控制维生素A的浓度能够协调毛囊干细胞的谱系可塑性,...
The importance of miRNAs in B cell lineage was emphasized by a study on a mouse gene knockout model in which Dicer, encoding a key enzyme responsible for the generation of miRNAs from their precursors [39], is deleted in a B cell-specific manner. B cell-specific deletion of Dicer ...