Mammalian chromosomes form a hierarchical structure within the cell nucleus, from chromatin loops, megabase (Mb)-sized topologically associating domains (TADs) to larger-scale A/B compartments. The molecular basis of the structures of loops and TADs has been actively studied. However, the A and B...
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Chromatin structure of the potential Z-forming sequence (dT-dG)n · (dC-dA)n: Evidence for an “alternating-B” conformationdoi:10.1016/0022-2836(85)90218-9The sequence (dT-dG)n · (dC-dA)n is the most abundant purine-pyrimidine dinucleotide repeat in eukaryotic genomes. This sequence ...
Chromatin higher-order structure and dynamics. Cold Spring Harb Perspect Biol 2010; 2: a000596. 69 Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J et al. The retino- blastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 1994; 79: 119...
Jolly CA. Dietary restriction and immune function. J Nutr. 2004;134:1853–6. Article CAS PubMed Google Scholar Okawa T, Nagai M, Hase K. Dietary intervention impacts immune cell functions and dynamics by inducing metabolic rewiring. Front Immunol. 2020;11:623989. Article CAS PubMed Google ...
Moreover, removal of repressive H3K27me3 and H3K9me3 leads to chromatin decondensation.36,37,38 Recent evidence suggests that miRNAs, such as mir-16 and mir-155, decrease AID and Blimp expression in B cells.38,39 In contrast, AID regulates DNA methylation dynamics in GC B cells.40,41 ...
Nucleosome positioning is known to be controlled by various factors such as preference of the DNA sequence to assume a nucleosome like structure, DNA methylation, higher order chromatin structure and presence of DNA binding proteins such as transcription factors [3]. Of these factors, the intrinsic...
(W R. Carlson, University of Iowa), (3) Genetic structure and organi- zation (J. S. Parker, University of Reading), (4) Pheno- typic effects (S. M. Bougourd, University of York), (5) Population dynamics (G. M. Hewitt, University of East Anglia), and (6) Summary (R. N. ...
Dynamics of genome architecture and chromatin function during human B cell differentiation and neoplastic transformation Article Open access 28 January 2021 Multiscale 3D genome rewiring during PTF1A-mediated somatic cell reprogramming into neural stem cells Article Open access 14 November 2024 Dynamic...