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摘要: A meeting entitled "Chromatin Structure and Dynamics: State-of-the-Art" organized by Jordanka Zlatanova and Sanford Leuba was held at the NIH from May 8–10, 2002. It was a timely meeting and addressed our current understanding of chromatin structure, dynamics, and function.关键词:...
Recent studies have demonstrated that chromatin architecture is linked to the progression of cancers. However, the roles of 3D structure and its dynamics in hormone-dependent breast cancer and endocrine resistance are largely unknown. Here we report the dynamics of 3D chromatin structure across a time...
Structure and dynamics of the chromatin remodeler ALC1 bound to a PARylated nucleosome. eLife 10, e71420 (2021). Article CAS PubMed PubMed Central Google Scholar Dao, H. T., Dul, B. E., Dann, G. P., Liszczak, G. P. & Muir, T. W. A basic motif anchoring ISWI to ...
Tissue differentiation is accompanied by genome-wide changes in the underlying chromatin structure and dynamics, or epigenome. By controlling when, where, and what regulatory factors have access to the underlying genomic DNA, the epigenome influences the cell's transcriptome and ultimately its function....
We discuss the dynamics of Tcra and Tcrd repertoire formation in the context of T cell development, and we consider how the recombination program is directed by localized changes in chromatin structure that regulate the accessibility of Tcra and Tcrd gene segments to the V(D)J recombinase. We...
DNA double-strand breaks (DSBs) occur in the context of a highly organized chromatin environment and are, thus, a significant threat to the epigenomic integrity of eukaryotic cells. Changes in break-proximal chromatin structure are thought to be a prerequisite for efficient DNA repair and may help...
Structure, Function and Dynamics of Chromatin Chromatin is a DNA-protein polymer, which consists of DNA, structural proteins, non-structural proteins and RNA. During interphase, chromatin encodes the information necessary to maintain the primary K Prakash - Springer International Publishing 被引量: 0发...
Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells Epigenetic mechanisms, including chromatin structure, chromatin dynamics and histone modifications play an important role for maintenance and differentiation of pluripotent embryonic stem cells. However, lit...
R-loop: an emerging regulator of chromatin dynamics: Table 1. The dynamic structure of chromatin, which exists in two conformational states: heterochromatin and euchromatin, alters the accessibility of the DNA to regu... Q Al-Hadid,Y Yang - 《Acta Biochimica Et Biophysica Sinica》 被引量: 6...