2024年1月12日,Journal of Translational Medicine杂志发表了题为“Single-cell sequencing reveals the heterogeneity of B cells and tertiary lymphoid structures in muscle-invasive bladder cancer”的研究论文,通过对12例膀胱癌患者的11,612个B细胞和55,392个T细胞进行单细胞RNA测序分析,研究人员发现了幼稚B细胞、...
Analysis of single-cell transcriptome data from NSCLC patients revealed that CD20 + CD22 + ADAM28 + BIR (ICI-responsive B cells) cells in TLSs predicted and contributed to the response to checkpoint immunotherapy [20]. Single-cell sequencing was applied to analyze the immune ...
在7月份,Cell杂志正式发表了一篇题为“Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-ThroughputSingle-Cell Sequencing of Convalescent Patients' B Cells”的研究文章,研究人员利用康复患者血液的B细胞筛选出多个高活性的中和抗体。其中编号为BD-368-2的抗体活性较高,在假病毒半抑制浓度实验中...
已有报道，外周血单个核细胞（Peripheral blood mononuclear cells，PBMCs）在多种神经退行性疾病中发挥促进作用。文章信息 文章题目：Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease 发表期刊：Experimental & Molecular Medicine 样本类型：4例AD患者（2例早期，2例晚...
单细胞测序技术(Single-Cell Sequencing):单细胞测序技术的应用提供了在个体细胞水平上理解遗传变异效应的新途径,使得可以精确地识别特定细胞类型和状态中的分子和遗传调控机制。 多群体遗传分析:通过比较不同种群的遗传数据,研究人员能够识别那些对于疾病具有不同贡献...
Single-cell RNA sequencing reveals B cell–related molecular biomarkers for Alzheimer’s disease Liu-Lin Xiong, Lu-Lu Xue, Ruo-Lan Du, Rui-Ze Niu, Li Chen, Jie Chen, Qiao Hu, Ya-Xin Tan, Hui-Fang Shang, Jia Liu, Chang-Yin Yu & Ting-Hua Wang Experimental & Molecul...
什么样的情况,会导致这样的单细胞细胞亚群的出现,该文献:《Single Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload-Driven Heart Failure Reveals Extent of Immune Activation》,我看了看,原文似乎是没有这样的单细胞亚群出现: 如果我们以pbmc3k为例 ...
摘要: University of Texas researchers have developed a high throughput method for sequencing individual B cell immunoglobulin receptors that keeps the link between their paired heavy and light variable chains intact. The next step is modifications to increase throughput and accuracy....
[2] Cao Y, Su B, Guo X, et al. Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells. Cell. 2020 Jul 9;182(1):73-84.e16. doi: 10.1016...
[11] J. Eberwine, J.Y. Sul, T. Bartfai, et al., The promise of single-cell sequencing, Nat Methods, 11 (2014) 25-27. [12] E. Pennisi, Chronicling embryos, cell by cell, gene by gene, Science, 360 (2018) 367. [13] E. Hedlund, Q. Deng, Single-cell RNA sequencing: Techn...