2020年5月20日,来自德国海德堡大学Department of Immunobiochemistry, Mannheim Institute for Innate Immunoscience的Adelheid Cerwenka教授课题组在Immunity(IF: 21.522)杂志上发表题为“Single-Cell RNA Sequencing of Tumor-Infiltrating NKC...
简介: 2020年5月20日,来自德国海德堡大学Department of Immunobiochemistry, Mannheim Institute for Innate Immunoscience的Adelheid Cerwenka教授课题组在Immunity(IF: 21.522)杂志上发表题为“Single-Cell RNA Sequencing of Tumor-Infiltrating NKCells Reveals that Inhibition of Transcription FactorHIF-1a Unleashes NK...
简介: 2020年5月20日,来自德国海德堡大学Department of Immunobiochemistry, Mannheim Institute for Innate Immunoscience的Adelheid Cerwenka教授课题组在Immunity(IF: 21.522)杂志上发表题为“Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1a Unleashes ...
单细胞RNA测序(scRNA-seq)是一项功能强大的技术,它采用不偏不倚的方法,而不仅限于细胞表面分子,有助于鉴定一个细胞群内的细胞多样性和异源转录特征。2020年6月16日,来自德国海德堡大学免疫生物化学系Mannheim固有免疫研究所的Adelheid Cerwenka课题组在Immunity发表文章“Single-Cell RNA Sequencing of Tumor-Infiltrati...
Birdshot chorioretinopathy is an inflammatory eye condition strongly associated with HLA-A29. Here the authors use a single cell RNA sequencing approach to characterise NK cell involvement in this disease and show that CD8brightCD244brightNK cells are associated with active disease. ...
英文题目:Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1a Unleashes NK Cell Activity 中文题目:肿瘤浸润NK细胞的单细胞RNA测序显示:抑制转录因子HIF-1α可释放NK细胞的抗肿瘤活性 发表杂志:immunity ...
可以看到上面的NK细胞细分,都是基于单个数据集,有很强烈的片面性,那么张泽民课题组的泛癌层面数据挖掘文章,2023年9月发表在CELL的《A pan-cancer single-cell panorama of human natural killer cells》,就很好的解决了这个问题。在NK单细胞亚群里面主要是CD56和CD16,其实对应的基因名字是NCAM1和FCGR3A ,它们在单...
这两个方向都需要掌握基础的单细胞转录组数据集的降维聚类分群,如果这个环节有问题就会造成数据挖掘文章很尴尬,比如:2023的文章:《 Integrated analysis of single‐cell and bulk RNA‐sequencing identifies a signature based on NK cell marker genes to predict prognosis and immunotherapy response in hepatocellular...
题目:Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1α Unleashes NK Cell Activity 译名:肿瘤浸润性NK细胞的单细胞RNA测序揭示了转录因子HIF-1α的抑制释放了NK细胞活性 DOI:10.1016/j.immuni.2020.05.001 主要内容 研究者利用单细胞RNA测序技术确定...
2020年5月20日,来自德国海德堡大学Department of Immunobiochemistry, Mannheim Institute for Innate Immunoscience的Adelheid Cerwenka教授课题组在Immunity(IF: 21.522)杂志上发表题为“Single-Cell RNA Sequencing of Tumor-Infiltrating NK Cells Reveals that Inhibition of Transcription Factor HIF-1a Unleashes NK Cel...