This is the first demonstration of a link between Vav and Rac in BCR internalization leading to antigen presentation to T cells.doi:10.1074/jbc.M109.014209Malhotra, S.Kovats, S.Zhang, W.Coggeshall, K. M.American Society for Biochemistry & Molecular Biology (ASBM...
Circumstantial evidence suggests that B cells may instruct T cells to break tolerance. Here, to test this hypothesis, we used a murine model in which a single B cell clone precipitates an autoreactive response resembling systemic lupus erythematosus (SLE). The initiating clone did not need to en...
Although the field is young, the emerging picture is that TIL- Bs promote antitumour immunity through their unique mode of antigen presentation to T cells; their role in assembling and perpetuating immunologically ‘hot’ tumour microenvironments involving T cells, myeloid cells and natural killer ce...
of mIg is required either for efficient antigen presentation, as measured by helper T cell activation, or for the B cell response to T cell help, since all the direct effects of anti-Ig on B cells require crosslinking of mIg. ... HP Tony - 《Journal of Experimental Medicine》 被引量:...
The first set of experiments demonstrated that GC B cells obtained three or more weeks after immunization could induce IL 2 production by T cells only by adding antigen to the cell cultures. In the next (table; see text) series, it was demonstrated that GC B cells isolated as early as 1...
T 细胞不能直接识别抗原,其活化需要抗原提呈细胞(antigen - presenting cells,APC)的辅助,而冻融后复苏标本 APC 活力受损。同时,由于慢性 HBV 感染时 T 细胞处于耗竭状态,患者外周血中 HBV 特异性 T 细胞频数低[7],导致目前针对 HBV...
B cells are essential components of the adaptive immune system and have important roles in the pathogenesis of several central nervous system (CNS) diseases. Besides producing antibodies, B cells perform other functions, including antigen presentation to T cells, production of proinflammatory cytokines ...
本文主要参考B.A. Heesters et al. Antigen Presentation to B cells. Trends Immunol (2016). 海斌的问题 与我同窗十几年的同学海斌在准备博士资格考试的时候,深深地被B细胞激活的问题困扰着。海斌知道B细胞的激活一定发生在特殊的次级淋巴组织,如脾脏或淋巴结中。因为只有在那里B细胞才有可能遇到它们的同源抗...
Among them, CD20 + B cells comprise memory B cells, naïve B cells, germinal center (GC) B cells and plasma cells [14]. Naïve B cells and memory B cells can facilitate antigen presentation to T cells, activating them to target tumor cells. In non-small cell lung cancer (NSCLC...
These data suggest that TPO-specific B cells ar 展开 关键词: antigen presentation iodide thyroid peroxidase thyroid peroxidase-specific B cells T cell proliferation DOI: 10.1046/j.1365-2249.2000.01087.x 被引量: 43 年份: 2000 收藏 引用 批量引用 报错 分享 ...