which have been trained to recognize a specific antigen, are saved as memory T and B cells. These memory cells are primed to proliferate and become active once again if there is a subsequent encounter with that specific pathogen. This allows the immune system to respond quicker...
E. Stromal cell–immune cell interactions. Annu Rev Immunol 29, 23–43 (2011). Article CAS PubMed Google Scholar Chan, T. D. et al. Elimination of germinal-center-derived self-reactive B cells is governed by the location and concentration of self-antigen. Immunity 37, 893–904 (2012)...
This study identifies that the pro-atherogenic functions of pDCs are mediated by MHC class II-restricted antigen presentation to CD4+ T cells and that this is independent of IFNα production. Article CAS PubMed PubMed Central Google Scholar Daissormont, I. T. et al. Plasmacytoid dendritic ...
Indeed, the β-cell is exquisitely unique. They are the sole source for providing insulin when needed, but also in that their metabolic machinery is distinctively set up for generating secondary signals to control β-cell function.[20]This provides an exclusive link for metabolic homeostasis to c...
The outstanding importance of antigen presentation for biomedical science as a whole of some of the major contributions in the field is best illustrated by the awarding of the Nobel Prizes in Physiology or Medicine for the discovery of the major histocompatibility complex (MHC) in 1980, the ...
; (B) The main reason why we would like to control living systems is to control how one cell behaves and in this way, determine what it does e.g. differentiation. The tools to achieve such fates are only beginning to come of age. In this review, some of the most innovati...
In addition, reduced ZnT4 expression is observed in the progression from benign to invasive prostate cancer [73]. Immune response ZIP10 is important for B-cell survival and function and along with ZIP6 is involved in antigen presentation to T cells [46, 52]. Dendritic cells are important ...
The resulting GalNAcα1-Thr/Ser, the Tn-antigen, is the substrate for further subsequent glycosylation steps, giving rise to eight different core structures (core 1 - core 8) depending on the cell type (Hanisch, 2001) (Fig. 2A). In gastrointestinal mucins, core 1–4 are most abundant (...
The eminently developed polymorphic nature of the classical MHC I molecules is reflected by a very high number of HLA-A, -B and -C alleles. Their strict peptide dependency has allowed the CD81 T-cell arm of the adaptive immune system to develop, providing long-lasting antigen-spe- cific ...
et al. Multiple defects in antigen presentation and T cell development by mice expressing cytoplasmic tail-truncated CD1d. Nat. Immunol. 3, 55–60 (2002). CAS PubMed Google Scholar Elewaut, D. et al. The adaptor protein AP-3 is required for CD1d-mediated antigen presentation of glycosph...