The unique characteristic of B cell antigen-presenting capacity lies in the ability of specific B cells to efficiently take up antigen via their immunoglobulin receptors and to present those antigen to antigen-specific helper T cells. Although this proposed mechanism of antigen presentation to T ...
If this were true, we hypothesized that the epitope spreading could potentially be bridged by B-cell antigen presentation across MHC haplotypes. To test this, we set up mixed BM chimeras using 564Igi MHCb/b BM as an autoreactive driver, WT MHCb/d BM and WT MHCd/d BM as potential ...
B细胞的分化过程主要可分为前B细胞(Pre-B cell)、不成熟B细胞(immature B cell)、成熟B细胞(mature B cell)、活化B细胞(activated B cell)和浆细胞(plasma cell)五个阶段。 B细胞分化的各… 思存 体液免疫(二):B细胞的前世今生(上) B细胞属于淋巴细胞的一种,由于其主要在骨髓(bone marrow)中发育而成得...
经过初级淋巴滤泡后的B细胞即为成熟B细胞(mature B cell),它们表面将高表达IgD、低表达IgM。如果没有遇到特异的抗原,则会离开初级淋巴滤泡回到血液中继续循环,称之为幼稚 (Naive) B细胞。(注意区分术语:幼稚B细胞是没有遇到抗原的B细胞,而不成熟B细胞是指未经过初级淋巴滤泡训练的B细胞!) 接触抗原 幼稚B细胞...
Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 23, 503–514 (2005). Article CAS PubMed Google Scholar Batista, F. D. & Harwood, N. E. The who, how and where of antigen presentation to B cells. Nature Rev. Immunol. 9, 15–27 (...
Antigen presentation by Ia + B cell hybridoma to H-2-restricted T cell hybridomas. Proc. Natl. Acad. Sci. USA. 79:3604-3607.Kappler, J., J. White, D. Wegmann, E. Mustain, and P. Mar- rack. 1982. Antigen presentation by Ia' B cell hybridomas to H-2-restricted T cell ...
AI-18 B cell IFN-γ receptor signalling promotes autoimmune germinal centresvia cell-intrinsic induction of BCL-6 Notably, B cells directly initiated CD4 + T cell activation and T follicular helper cell formation via MHC Class II (MHC-II)-dependent antigen presentation. In addition, activated T...
'B cell antigen receptor (BCR) association with lipid rafts, the actin cytoskeleton, and clathrin-coated pits influences B cell signaling and antigen presentation. Although all three cellular structures have been separately implicated in BCR internalization, the relationship between them has not been cl...
3. Lee DSW, Rojas OL, Gommerman JL. B cell depletion therapies in autoimmune disease: advances and mechanistic insights[J]. Nat Rev Drug Discov, 2021 ,20(3):179-199. 4. Heesters BA, van der Poel CE, Das A, et al. Antigen Presentation to B Cells[J].Trends Immunol, 2016, 37(12...
Antigen presentation to T cell hybridomas by a macrophage cell line: an inducible function. We have investigated the ability of an Ia-, nonantigen-presenting macrophage tumor cell line, P388D, (H-2d), to present antigen to T cell hybridomas after incubation in a lymphokine-containing prepar...