In addition, lung epithelial MHC-II is needed for surface expression of PD-L1, which engages its ligand PD-1 to constrain lung CD4+ TRM cell phenotypes. Thus, we establish epithelial antigen presentation as a critical regulator of CD4+ TRM cell function and identify epithelial-CD4+ TRM cell ...
11. Barrier epithelial cells recruit and maintain CD8+TRMcells near the sites of antigen encounter, and reactivate them in the tissues via local antigen presentation12,13. In contrast to CD8+TRMcell effects, epithelial roles governing CD4+TRMlocations...
We conclude that these cell lines have characteristics most consistent with a proximal tubular origin. They also bear characteristics of accessory cells such as processing and presentation of antigen and TNF-alpha gene expression. We speculate that PT have the capacity to participate in the ...
Although intestinal epithelial cells (IECs) can express major histocompatibility complex class II (MHC II), especially during intestinal inflammation, it remains unclear if antigen presentation by IECs favors pro- or anti-inflammatory CD4+T-cell responses. Using selective gene ablation of MHC II in ...
epithelial cells by their heart and blood vessel-specific location, morphology and expression ofvimentinrather than keratins, as well as specificcell surface antigens. The liver and pancreas regenerate by reproduction of parental cells after surgical loss of tissue, but their ductules harbor stem ...
A Columnar Epithelial Cell is a type of cell found in the gallbladder that stains for keratin 7 (K7) and expresses cell adhesion molecule (CAM) 5.2 and anion exchanger (AE) 1 and 3. These cells also show apical cytoplasmic staining for carcinoembryonic antigen (CEA). ...
Dong H, Chen X. Immunoregulatory role of B7-H1 in chronicity of inflammatory responses. Cell Mol Immunol. 2006;3(3):179–87. PubMedCASGoogle Scholar Leon MP, Bassendine MF, Wilson JL, Ali S, Thick M, Kirby JA. Immunogenicity of biliary epithelium: investigation of antigen presentation to...
Also, the mucosa comprises a range of different cell types known to be critical in orchestrating such responses and a specific role of airway epithelial cells within that process has not been fully elucidated5,6. Airway epithelial cell culture models are widely used, as such cells are easy to...
- 《American Journal of Respiratory Cell & Molecular Biology》 被引量: 195发表: 1999年 Downregulation of Integrin β4 Decreases the Ability of Airway Epithelial Cells to Present Antigens Airway epithelial cells have been demonstrated to be accessory antigen presentation cells (APC) capable of ...
We isolated many clones derived from thesurvivors of a transformed mouse ovarian epithelial cell line IG-10 in immune- competent mice and found that the clones displayed diverse phenotypes. Most clones were deficient in components of the MHC-I antigen presentation pathway. Soft-agarose colony assays...