The use of synthetic antigen-presenting cells to activate and expand engineered T cells for the treatment of cancers typically results in therapies that are suboptimal in effectiveness and durability. Here we describe a high-throughput microfluidic syste
e-f, Splenic antigen-presenting cells (APCs: DCs or B cells) were sort-purified from steady state (e) or CFA-treated mice (f, d10) and co-cultured with 2D2 T cells previously stained with violet cell trace violet. Groups included 2D2 T cells alone (no APC), 2D2 T cells plus ...
These CTLs are specific for allopeptides presented by self class I molecules, indicating that host antigen presenting cells have acquired these exogenous antigens. In recent years, additional data have accumulated showing that denatured proteins [89], soluble antigens associated with cellular debris ...
expansion, followed by subsequent migration of the activated CD8+into peripheral organs where it can recognise and eliminate infected cells. Infected non-professional antigen-presenting cells (n-pAPC) can, in principal, also prime T cells if they are able to reach the lymphatics (dotted arrow)....
Colorectal cancer (CRC) is the third most common cancer and the second leading cause of cancer deaths worldwide. Besides common therapeutic approaches, such as surgery, chemotherapy, and radiotherapy, novel therapeutic approaches, including immunotherapy
GL7 high-expressing B cells show higher antibody production and antigen presenting capacity. Product Details Technical data sheet Product Details Isotype Control Alexa Fluor® 488 Rat IgM, κ Isotype Ctrl Verified Reactivity Mouse, Human Antibody Type Monoclonal Host...
Implicit to this model of counteraction is the processing of an immunogenic peptide epitope (antigen processing) and its presentation on the surface of a team of cells, referred to as APCs (Antigen Presenting Cells) (antigen presentation...
Antiviral CD8+ T cell immunity depends on the integration of various contextual cues, but how antigen-presenting cells (APCs) consolidate these signals for decoding by T cells remains unclear. Here, we describe gradual interferon-α/interferon-β (IFNα/
cells after 24 h (Fig.5c). 41BBL is expressed on antigen-presenting cells that, upon ligation to its cognate receptors, activates both CD4 and CD8 T cells and induces their proliferation33,34. We found that that 41BBL was upregulated with eLNP stimulation in cDC2 (p = 0.0283) ...
It is becoming increasingly apparent that the innate and adaptive components of the immune system are tightly linked. For example, it is well known that inflammation-inducing adjuvants enhance T cell responses, presumably by the activation of antigen-presenting cells leading to more efficient uptake ...