因此，新一代PROTAC技术提出了 “降解可控性”的概念，给降解剂的研发带来了新的挑战。不过，更大的挑战意味着更多的机遇。近日，中国药科大学尤启冬/姜正羽教授团队报道了利用Azo-PROTAC技术实现光诱导的可控性小分子蛋白降解剂，提高了降解精度，避免可能毒性。该成果发表在药物化学期刊《Journal of Medicinal Chemist...
With the presence of 50CimL1 131I, the azoPROTAC can effectively down‐regulate BRD4 and c‐Myc levels in 4T1 cells at a similar level as it does under light irradiation (405nm, 60mWcm2). What's more, the degradation of BRD4 can further benefit the131I‐based radiotherapy. The in ...