Ballesteros-Álvarez J, Andersen JK. mTORC2: the other mTOR in autophagy regulation. Aging Cell. 2021;20(8):e13431. Article Google Scholar Betz C, Hall MN. Where is mTOR and what is it doing there? J Cell Biol. 2013;203:563–74. Article CAS Google Scholar Download references ...
A Na+,K+-ATPase-mediated function is an essential upstream component of autosis; however, it is not known how this ion pump leads to the downstream morphological changes and demise of the cell. Na+,K+-ATPase may also function upstream of other death pathways, as neonatal rat treatment with...
If STING1 is an autophagy receptor, what is its core substrate? Why does STING1 share a common upstream activation signal during DNA damage but can then lead to different cell death pathways? In addition to the ER, what is the function of STING1 in other subcellular organelles? How do ...
However, autophagy mutant worms gradually accumulate P granules to form what is referred to as PGL granules that contain PGL-1 protein aggregates [33]. This selective autophagy in somatic cells is mediated by zygotically derived SEPA-1, an autophagy adapter molecule that directly interacts with ...
In 1927, Nathan Chandler Foot22 stated, in an article in the AJP, that what were then called dust cells in the lung originated from blood monocytes, not from epithelial tissue. By the mid-20th century, it was established that mononuclear phagocytes originate as myeloid cells in the bone ...
Betz C, Hall MN (2013) Where is mTOR and what is it doing there? J Cell Biol 203:563–574 Article PubMed Central CAS PubMed Google Scholar Betz C, Stracka D, Prescianotto-Baschong C, Frieden M, Demaurex N, Hall MN (2013) Feature article: mTOR complex 2-Akt signaling at mitoch...
2 There are examples in Drosoph- ila, however, in which the autophagic machinery is funda- mentally involved in the cell death process itself,4 although it is unclear to what extent such bona fide autophagic cell death occurs in mammals. 209 ...
Autophagy is one of the main degradation and recycling processes aimed at maintaining cellular homeostasis [11]. It functions by clearing misfolded proteins and defective organelles, and by recycling cytosolic components under stress [12]. In eukaryotic cells, there are three major types of autophagy...
While an indication that autophagy takes place in these parasites, the limited number of proteins identified seemed to point to a less complex autophagy pathway than what is observed in yeasts. Or alternatively, some different, still unknown proteins, not homologous to yeast ATGs, may be involved...
it is still very new. Things will probably be wonky for a while. This is made explicit by the "Beta" trove classifier, as well as by the "b" in the version number. What this means for you is thatuntil the formatter becomes stable, you should expect some formatting to change in the...