3-甲基腺嘌呤是一种自噬抑制剂,对新陈代谢有多种影响。| Caro, LH., et al. 1988. Eur J Biochem. 175: 325-9. PMID: 3402459 Autophagy Inhibitor, 3-MA (5142-23-4) 调制目标 抑制剂: 激活剂:
Autophagy was activated significantly after I/R injury, which was partially inhibited by 3‐MA and BAF. Pretreatment with both 3‐MA and BAF almost completely inhibited nuclear translocation, spatial overlap, and combination of RIP3, AIF, and CypA proteins. These findings suggest that after global...
接收到3-Methyladenine (Autophagy Inhibitor, 3-MA)产品后,置于4°C温度下保存。 其他 Usbiological公司是美国著名的抗体和生化试剂供应商,生产世界上种类最多的抗体,用于Western Blot、免疫沉淀、免疫荧光、免疫组化和流式细胞术等多种检测方法。Usbiological公司现已拥有超过50,19234种抗体、抗原和生化产品,为科研...
3-Methyladenine (also known as 3-MA) is an inhibitor of phosphatidylinositol 3-kinases (PI3K). PI3K plays an important role in many biological processes, including controlling the activation of mTOR, a key regulator of autophagy. Autophagy is a pathway by which cytoplasmic constituents, including ...
产品活性:3-Methyladenine (3-MA) 是 PI3K 的抑制剂。它通过抑制class III PI3K广泛作为自噬 (autophagy) 的抑制剂使用。 生物活性:3-Methyladenine (3-MA) 是一种PI3K抑制剂。 3-甲基腺嘌呤通过对 III 类 PI3K[1]的抑制作用而成为一种广泛使用的自噬抑制剂。 IC50 和目标:IC50:25 μM (Vps34)、60 μ...
The autophagy inhibitor 3-MA increased the steady-state level of ataxin-3 and stabilized SUMO-modified ataxin-3 more prominently than the proteasome inhibitor MG132. Interestingly, SUMO-1 overexpression enhanced the co-localization of ataxin-3 and autophagy marker LC3 without increasing LC3 puncta ...
Abbreviations : 3-MA: 3-methyladenine; AD: Alzheimer disease; ATG: autophagy-related; BECN1: beclin 1; BM: bone marrow; CD: cluster of differentiation; EAE: experimental autoimmune encephalomyelitis; IL: interleukin; INF: interferon; LAP: LC3-associated phagocytosis; MAP1LC3/LC3: microtubule ...
表明,自噬是自身抗原处理所必需的,自噬缺陷会影响DC的T细胞激活能力。 图5. DC特异性PIK3C3缺失影响其激活T细胞 这项研究揭示了,Pik3c3缺陷的DC在中枢神经系统中表现出T细胞激活能力的减弱,导致DC特异性Pik3c3缺陷小鼠EAE的发生率和严重程...
Bubble pre‐conditioning for 1minutes resulted in increased cell viability and decreased apoptosis rate compared with no pre‐conditioning, and 30‐minutes pre‐conditioning induced opposing changes, all of which were inhibited by 3‐MA. In conclusion, autophagy was involved and played a biphasic ...
are only partially understood and the role of autophagy on leukaemia development and treatment is only recently being investigated, in this study, by using Chloroquine (CQ) and 3-methyladenine (3MA) as autophagy inhibitors, we aim to evaluate the contribution of an autophagic mechanism to Cytarabin...