近期,广州医科大附属第三医院和美国得克萨斯大学西南医学中心合作,利用基于质谱的蛋白质组学鉴定了参与铁死亡的一个关键膜蛋白HPCAL1,并深入研究了其作用机制及潜在的靶向治疗可能性。研究成果以“Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis”为题,发表在Autophagy(IF:13.391)上。
铁死亡(ferroptosis)是近几年发现的一种新的细胞死亡方式，是在小分子物质诱导下发生的氧化性细胞死亡，具有铁离子依赖性。其发生是细胞内脂质活性氧(reactive oxygen species，ROS)生成与降解的平衡失调所致。铁死亡诱导剂通过不同的通路直接或间接作用于谷胱甘肽过氧化物酶(glutathione peroxidase，GPXs)，导致细胞抗氧化...
2024年10月3日,中南大学陶勇和陶永光共同通讯在Autophagy(IF=14.6)在线发表题为“USP13 facilitates a ferroptosis-to-autophagy switch by activation of the NFE2L2/NRF2-SQSTM1/p62-KEAP1 axis dependent on the KRAS signaling pathw...
近日,中南大学基础医学院/肿瘤研究所陶永光研究员与张彬副教授在自噬期刊Autophagy发表题为USP13 facilitates a ferroptosis-to-autophagy switch by activation of the NFE2L2/NRF2-SQSTM1/p62-KEAP1 axis dependent on the KRAS signaling pathway...
2025年2月23日,苏州大学畅磊和张增利共同通讯在Autophagy(IF=14.6)在线发表题为“Autophagy induced by mechanical stress sensitizes cells to ferroptosis by the NCOA4-FTH1 axis”的研究论文。该研究揭示,增强的机械张力会使细胞对铁死亡敏感,而降低的机械张力则会使细胞产生抗性。
Ferroptosis, a programmed cell death, has been identified and associated with cancer and various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS)-dependent cell death related to iron accumulation and lipid peroxidation, which is
ferroptosis, has the potential to upregulate pyroptosis-associated proteins [5]. These indicate that the pyroptosis and ferroptosis pathways can be activated concurrently. Conversely, ferroptosis inhibitors can inhibit pyroptosis [5]. Nor are iron ions the exclusive inducing condition for ferroptosis, ...
By exploring the complex crosstalk between ferroptosis and autophagy, we hope to broaden horizons of cancer therapy.doi:10.1186/s12967-024-06059-wLiu, XingyuCancer Center, The First Hospital of Jilin University, Changchun, ChinaTuerxun, Halahati...
2022年8月22日,广州医科大学Liu Jiao及西南医学中心唐道林共同通讯在Autophagy(IF=13)在线发表题为“TMEM164 is a new determinant of autophagy-dependent ferroptosis”的研究论文,报告了TMEM164(跨膜蛋白 164)在铁死亡期间而非饥饿期间选...
Ferroptosis and autophagy are two main forms of regulated cell death (RCD). Ferroptosis is a newly identified RCD driven by iron accumulation and lipid peroxidation. Autophagy is a self-degradation system through membrane rearrangement. Autophagy regulates the metabolic balance between synthesis, degradati...