Autophagy was activated significantly after I/R injury, which was partially inhibited by 3‐MA and BAF. Pretreatment with both 3‐MA and BAF almost completely inhibited nuclear translocation, spatial overlap, and combination of RIP3, AIF, and CypA proteins. These findings suggest that after global...
3-Methyladenine (also known as 3-MA) is an inhibitor of phosphatidylinositol 3-kinases (PI3K). PI3K plays an important role in many biological processes, including controlling the activation of mTOR, a key regulator of autophagy. Autophagy is a pathway by which cytoplasmic constituents, including ...
are only partially understood and the role of autophagy on leukaemia development and treatment is only recently being investigated, in this study, by using Chloroquine (CQ) and 3-methyladenine (3MA) as autophagy inhibitors, we aim to evaluate the contribution of an autophagic mechanism to Cytarabin...
Exposure of bovine oocytes to heat shock in the presence of 10 mM 3MA (3MA-41 °C) reduced transcript abundance of oocyteHAS2(P < 0.05; Fig.4A),MTIF3(P < 0.05; Fig.4C), andHSF1(P = 0.05; Fig.4E) compared to heat-shocked oocytes in 0 mM 3MA (IVM-41 °C). ...
基因克隆原核表达前列腺肿瘤创伤分子伴侣介导的自噬凋亡光动力治疗亚洲牛带绦虫乳腺肿瘤pc12细胞p62/sqstmingalrngalmtorhela细胞c6胶质瘤细胞atp耗竭apg3基因ampk5-氨基乙酰丙酸3-甲基腺嘌呤(3-ma)3-甲基腺嘌呤1-甲基-4-苯基吡啶 推荐指数19543332222222211111111111111111111111111111111111111 2010年序号...
3-MA inhibits A2E-induced autophagy in RPE cells Our results described above revealed that A2E incubated with RPE cells induced autophagy, reaching a peak at 12 h (Figure 2), and significantly increased the levels of inflammatory factors and VEGFA (Figure 1). On the basis of previous rep...
The results showed that Golgi-associated vesicle disorganization was exacerbated with the 3-MA and beclin-1 siRNA pretreatments, but decreased with the rapamycin pretreatment, and the expression of GOPC and DPY19L2 was also altered. These results indicated that autophagy might be involved in the ...
3. Regulation of autophagy induction 4. Autophagy steps 5. Wnt signaling pathway 6. Role of autophagy and Wnt signaling in proliferation and differentiation 7. Cross talk between Wnt/β-catenin signaling and autophagy 8. Concluding remarks Declaration of competing interest ReferencesShow full outline ...
(3-MA) treatment, decreased the toxic effects or delayed neuronal loss after noxious treatments [103,253,254,260]. Likewise, knockdown ofATG5orBECN1by RNAi reduced cell death in photoreceptor cells that were exposed to oxidative stress [253]. Maybe most convincingly,Atg7flox/flox;nestin-Cre ...
The autophagy inhibitor 3-MA sensitized resistant HNC cells to RITA treatment via the dual inhibition of molecules related to the autophagy and antioxidant systems. Silencing of the p62 gene augmented the combined effects. The effective antitumor activity of RITA plus 3-MA was also confirmed in ...