Purpose of Review As the primary process involved in regulating cellular hemostasis, autophagy has dual functions in cancer by either promoting or suppressing tumor growth. This article reviews recent research on the role of autophagy in cancer therapy, and discusses several novel anti-cancer agents ...
Breast Cancer (2024) 31:195–204 https://doi.org/10.1007/s12282-023-01541-7 REVIEW ARTICLE Advances in the study of autophagy in breast cancer Tang Yu1,2 · Liu Rui1 · Zhao Jiumei3 · Li Ziwei4 · Hu Ying5 Received: 13 November 2023 / Accepted: 25 ...
The emergence of nano-drug delivery systems with different functions has led to very significant advances in cancer treatment, solving many of the problems that have stymied conventional pharmacological agents. There is also a unique connection between NPs and autophagy. Because of their size, NPs ...
autophagy in 2016 [2]. Especially, recent advances in researching the various substrates of autophagy and the temporal and spatial effects of impaired autophagy regulation on tissue homeostasis have revealed a complicated and multifaceted association between autophagy and diseases. Autophagy has emerged as...
Autophagy and digestive disorders: advances in understanding and therapeutic approaches. Biomol Therap. 2021;29:353–64. Article Google Scholar Larabi A, Barnich N, Nguyen HTT. New insights into the interplay between autophagy, gut microbiota and inflammatory responses in IBD. Autophagy. 2020;16:...
Despite major advances in how autophagy regulates inflammatory reactions toward microbes, many challenges remain, including distinguishing autophagy from closely related pathways such as LC3-associated phagocytosis. Here, we review the role of autophagy in microbial pathogenesis at the level of organismal ...
The identification in multicellular organisms of orthologs of autophagy-related yeast genes has led to some of the major advances in the molecular dissection of the pathway in the last decade. In higher eukaryotes, autophagy is much more than a ‘stress response’ pathway. The complexity of ...
In this review, we systemically presented recent advances in indole alkaloids as anticancer agents by regulating autophagy categorized as follows: (1) targeting the PI3K/Akt/mTOR signaling pathway, (2) targeting the MAPK signaling pathway, (3) targeting Beclin-1, (4) targeting the ROS signaling ...
This paper advances the understanding of amino acid sensing by showing that amino acids are detected within the lysosome by the vacuolar V-ATPase. CAS PubMed PubMed Central Google Scholar Hosokawa, N. et al. Nutrient-dependent mTORC1 association with the ULK1–Atg13–FIP200 complex required ...
Advances in the genetics of Parkinson disease. Nat. Rev. Neurol. 9, 445–454 (2013). Article PubMed CAS Google Scholar Moors, T. et al. Lysosomal dysfunction and alpha-synuclein aggregation in Parkinson’s disease: diagnostic links. Movement Disord. 31, 791–801 (2016). Article PubMed ...