The Human Protein Atlas contains images of histological sections from normal and cancer tissues obtained by immunohistochemistry. Antibodies are labeled with DAB (3,3'-diaminobenzidine) and the resulting brown staining indicates where an antibody has bound to its corresponding antigen. Check https://...
Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in hea...
The Human Protein Atlas program has already contributed to several thousands of publications in the field of human biology and disease and it was recently selected by the organization ELIXIR as a European core resource, due to its fundamental importance for a wider life science commun...
By subsequently using these affinity molecules for detection of the corresponding proteins in a wide range of platforms, important information can be gained. This article focuses on strategies to profile protein levels and in particular the human protein atlas initiative and the use of microarray ...
TheHuman Protein Atlas (HPA) project released the first version of a complete tissue-based map of human protein expression using antibodies in November 2014. In close partner ship with the HPA project, we continue to develop advanced antibodies and advanced reagents for Mass Spectrometry (MS)-base...
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protein 3); these examples also illustrate how well fine structures are distinguished, such as the assignment of heterochromatin protein 1 binding protein to nuclear speckles and centromere protein T to nuclear bodies (that is, centromeres). Similarly, the proteins Enhancer of mRNA decapping 4 and...
Here, we present the design and analysis of the results from the competition Human Protein Atlas – Single-Cell Classification hosted on the Kaggle platform. This represents a crowd-sourced competition to develop machine learning models trained on limited annotations to label single-cell protein ...
An attractive path forward in proteomics is to experimentally annotate the human protein complement of the genome in a genecentric manner. Using antibodies, it might be possible to design protein-specific probes for a representative protein from every protein-coding gene and to subsequently use the ...
HuBMAP联合体(https://hubmapconsortium.org/)将与其它正在进行中的项目积极开展工作,这些项目包括人类细胞图谱计划(Human Cell Atlas) 、人类蛋白图谱(Human Protein Atlas) 、生命时间项目(LIfeTime)以及NIH资助的靶向特殊器官和组织的联合体(包括脑、肺、肾、泌尿生殖器官)以及其他新出现的程序。