These efforts include the Human Proteome Map and the Proteomics DB , based on mass spectrometry, as well as the Human Protein Atlas project . The Human Protein Atlas by Uhlen et al. focuses on an integrated omics approach, combining antibody-based protein expression profiling using standardized ...
We are a Swedish biotech company founded in 2006, started by researchers from the Human Protein Atlas project. The Human Protein Atlas is a Swedish research project that started in 2003, with the goal to create an immunohistochemistry based map of human protein expression and localisation in norma...
Cellular atlases are unlocking the mysteries of the human body The Human Cell Atlas is yielding detailed maps of human tissues and systems throughout life, along with methods to handle single-cell data. Four scientists reflect on how the project is transforming our understanding of human biology...
Pinpointing subcellular protein localizations from microscopy images is easy to the trained eye, but challenging to automate. Based on the Human Protein Atlas image collection, we held a competition to identify deep learning solutions to solve this task. Challenges included training on highly imbalanced...
Here, we present the design and analysis of the results from the competition Human Protein Atlas – Single-Cell Classification hosted on the Kaggle platform. This represents a crowd-sourced competition to develop machine learning models trained on limited annotations to label single-cell protein ...
Available from: http://www.idf.org/diabetesatlas/5e/Update2012 Google Scholar [3] P. Gaudet neXtProt: organizing protein knowledge in the context of human proteome projects Journal of Proteomic Research, 12 (1) (2013), pp. 293-298 Google Scholar [4] HUPO. Human Proteome Project (HPP). ...
12 The Genotype-Tissue Expression Project (GTEx),13 and the Human Protein Atlas (HPA)5 has been recently published as two independent and comprehensive RNA-seq data sources on 30 human tissues. In HPA study, one of the major conclusion of the paper was that the largest fraction of the ...
We extend this concept to identify cell types of origin using the Tabula Sapiens transcriptomic cell atlas as well as individual tissue transcriptomic cell atlases in combination with the Human Protein Atlas RNA consensus dataset. We define cell type signature scores, which allow the inference of ...
et al. HPAanalyze: an R package that facilitates the retrieval and analysis of the Human Protein Atlas data. BMC Bioinformatics 20, 463 (2019) https://doi.org/10.1186/s12859-019-3059-zBackgroundThe Human Protein Atlas (HPA) is a comprehensive resource for exploration of human proteome which...
Although plasma proteins have important roles in biological processes and are the direct targets of many drugs, the genetic factors that control inter-individual variation in plasma protein levels are not well understood. Here we characterize the genetic architecture of the human plasma proteome in hea...