1.Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma. and spring 机译:Atg5-Atg12 / Atg16L1自噬蛋白复合物在干扰素γ的抗病毒活性中的非降解作用。 Hwang S ,Maloney NS ,Bruinsma MW - Cell Host & Microbe - 2012 2.The roles of in...
While ATG16L2 stabilizes ATG5 and enables ATG12–ATG5 conjugation, this endogenous dominant-negative inhibitor simultaneously displaces ATG16L1, resulting in its proteasomal degradation and a block in autophagy. Thus, collectively, our findings provide novel insights into ATG12–ATG5-ATG16L1 complex ...
(Target of rapamycin) through phosphorylation of autophagy protein APG1.ATG5,another member of the autophagy protein family,forms a conjugate with ATG12;this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy.This conjugate also associates with innate ...
近年来,人们发现自吞噬现象在神经系统疾病中发挥重要作用,而自噬相关基因(ATG)5和7是参与自噬体形成的关键基因[5,6]。有研究发现,ATG5和ATG7基因突变会引起自噬途径失活,神经元内异常蛋白大量聚集,导致神经元出现进行性病变[7]。本研究选取2015年2月-2017年2月宁波大学医学院附属鄞州医院确诊的宁波地区MR儿童264例...