The hyperactivity of Tn5 transposase makes the ATAC-seq protocol a simple, time-efficient method that requires 500–50,000 cells [9]. The sensitivity and specificity are comparable to DNase-seq but superior to FAIRE-seq where both methods require millions of cells as input material [9]. Becaus...
ATAC-seq (Assays for Transposase-Accessible Chromatin using sequencing) is a recently developed technique for genome-wide analysis of chromatin accessibility. Compared to earlier methods for assaying chromatin accessibility, ATAC-seq is faster and easier to perform, does not require cross-linking, has ...