Bidirectional astrocyte-neuron communication synchronizes astrocyte maturation with synapse development. An emerging body of evidence supports the hypothesis that in NDDs, deficits in astrocyte-neuron communication underlie errors in synaptic circuit development. Here we will review and discuss these findings,...
Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes Borsuk, J. Paszko, et al., "Astrocyte- neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes," Glia, 63... P Mamczur,B Borsuk,J Paszko,...
Although it remains unclear whether the observed astrocyte-to-neuron conversion may be caused by leakage from existing neurons, the current scRNA-seq and immunostaining data suggest the existence of a subclass of astrocytes or astrocyte-like cells with a higher propensity to convert to neuronal ...
The precise onset, temporal progression and spatial extent of neuron-tumor crosstalk in brain with Glioblastoma (GBM) are not fully understood. Here authors, using a genetic GBM mouse model, show widespread glutamate accumulation, chronic neural activity disruption between cells and brain areas, depend...
Glial-neuron crosstalk in health and disease: A focus on metabolism, obesity, and cognitive impairment Neurobiology of Disease Journal2022, Neurobiology of Disease Rosemary E. Henn, ... Eva L. Feldman Search terms “astrocyte”, “axo-glial”, “brain”, “cell”, “central nervous system”,...
Brain iron dysregulation associated with aging is closely related to motor and cognitive impairments in neurodegenerative diseases. The regulation of iron traffic at the blood-brain barrier (BBB) is crucial to maintain brain iron homeostasis. However, th
4, 5 Dysfunctional neuron–astrocyte crosstalk is known to be a central feature of neurodegenerative diseases.6, 7 Astrocytes exert both toxic and protective effects on neurons in a context-dependent manner. The neurotoxic effects of astrocytes are mediated in part through pro-inflammatory cytokines,...
(100 and 200 days), possibly because aged environment may have more factors that stimulate astrocyte maturation compared to young adults. The differentiated astrocytes of the transplantation prevented the motoneuron loss that is associated with aging, even though improved motor performance was not ...
Astrocyte Crosstalk in CNS Inflammation We explore mechanisms of crosstalk between astrocytes and other cells in the CNS in the context of neuroinflammation and neurodegeneration and discuss how these interactions shape pathological outcomes.doi:10.1016/j.neuron.2020.08.012Mathias ... M Linnerbauer,MA Wh...
Astrocytic-neuronal crosstalk: implications for neuroprotection from brain injury Neurosci. Res., 71 (2) (2011), pp. 107-113 Google Scholar [14] W. Cui, et al. Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain Glia, 34 (4) (2001...