therapeutic drug monitoringhypersensitivity reactionsAcute lymphoblastic leukemia (ALL) is a rare disease in infants. Asparaginase is an essential part of the treatment, and there Acute is a need to evaluate the efficiency and safety of this drug in this age group. We evaluated the pharmacokinetics ...
Author VM would like to thank Tim Lammens and the Asparaginase therapeutic drug monitoring laboratorium for performing the PK analyses and all involved hospitals for data collection. CR wishes to thank the Comitato ML Verga (Monza, Italy), the Association “Insieme ad Andrea si può” ONLUS (Je...
The coefficient of correlation for dilution linearity was determined as r2=0.986 for dilutions up to 1:20. This method combined with sensitive methods for the quantification of l-Asn will allow bioequivalence studies and individualized therapeutic drug monitoring of different ASNASE preparations. 展开 ...
Also, a therapeutic drug–monitoring program is now used to individualize the PEGasparaginase dose and to detect silent inactivation. In case of allergy or silent inactivation, patients are switched to Erwinia asparaginase with therapeutic drug monitoring to allow individualized dosing of Erwinia ...
Therapeutic drug monitoring of asparaginase in the ALL-BFM 2000 protocol between 2000 and 2007 BackgroundOn a voluntary basis therapeutic drug monitoring (TDM) was implemented in the ALL-BFM 2000 protocol for the three currently used asparaginase (AS... Dominik,Schrey,Stephan,... - 《Pediatric ...
Analytical validation of a microplate reader based method for the therapeutic drug monitoring of L-asparaginase in human serum. Anal Biochem 2002; 309: 117–126. Article CAS Google Scholar Lenda K, Svenneby G . Rapid high-performance liquid chromatographic determination of amino acids in ...
Over 1000 EcA variants were screened for desirable therapeutic properties. The main aim was to improve the stability and reduce immunogenicity and glutaminase activity without compromising the asparaginase activity of the variants [5,25]. Here, we report the activity, thermostability, cytotoxicity, ...
and therefore may interfere with the action of drugs such as methotrexate that require cell replication for their antineoplastic effect.1 It has been suggested that a 24-hour inter- val between methotrexate and a subsequent dose of asparaginase permits at least an additive therapeutic effect.2 1....
The discovery of the tumour-inhibitory properties of asparaginase began 50 years ago with the observation that guinea-pig serum-treated lymphoma-bearing mice underwent rapid and often complete regression. Soon afterwards, the asparaginase of bacterial origin was isolated. The asparaginases of bacterial ...
Another aspect to consider for l-asparaginase treatment is the drug functional stability after administration. High levels of l-asparaginase activity in patients’ blood are desirable to reach the therapeutic effect, mainly during induction therapy. However, in some cases, circulating l-asparaginase ...