拼音名:Zhusheyong L-Mendongxian'anmei 英文名:L-Asparaginase for Injection 书页号:E6-16 本品为L-门冬酰胺酶及适量稳定剂和赋型剂的无菌冻干品,其效价应为标示量的85.0～115.0%。 【性状】 本品为白色冻干块状物。 【鉴别】 (1)取本品,加水制成每1ml中含1000单位的溶液,照L-门冬酰胺酶项下鉴别(1)...
L-ASPARAGINE AMIDOHYDROLASE - L-asparaginase (E. Coli) for injection Authoritative Data Verified Data This product is a sterile lyophilized product of L-asparaginase (E. Coli) with appropriate amount of stabilizer and excipient. The titer of L-asparaginase (E. Coli) should be 85.0% to 115.0% ...
L.asparaginase作用机制及其在髓系白血病治疗中的应用 中文详细摘要 左旋门冬酰胺酶(L-Aspara沓naSe,L—Asp)是临床上治疗儿童急性淋巴细胞白血 病(ALL)和非霍奇金氏淋巴瘤(NHL)主要药物之一。既往人们评价L.Asp抗肿 瘤作用的效果通常是以是否耗竭血浆中Asn为标准。但是临床治疗中发现不同类型 ...
Injections of polyethylene glycol (PEG)-L-asparaginase or L-asparaginase were given to two rabbits each at doses of 40 units/kg. Ten min following injection of either enzyme preparation, the plasma enzyme concentration was approximately 1 unit/ml. This level decreased steadily in the rabbits give...
For the first method an asparaginase reactor was integrated in a gas-diffusion flow-injection system. This method is based on the measurement of the pH change in an acceptor solution caused by diffused ammonia generated by asparagine hydrolysis catalzyed by immobilized asparaginase. The detection was...
Intrathecal injection of E. coli asparaginase resulted in complete depletion of CSF asparagine for at least 5 days. A similar period of CSF asparagine depletion was observed following i.v. administration of L-asparaginase. Similar results were found in seven patients undergoing systemic L-asparaginase...
It turned out that only nitrile 6 was suitable for the envisioned β-amino acid synthesis, since ... Peter,Gmeiner - 《Archiv Der Pharmazie》 被引量: 60发表: 1991年 l-asparaginase: an effective agent in the treatment of acute lymphoblastic leukemia. It catalyzes the hydrolysis of amino ...
(Cullenet al., 1990). Urease was immobilized on the surface of the first electrode pair in a gel layer; on the second pair there was L-asparaginase; on the third pair a three-enzyme system –‘urease–creatinase-creatininase’. This sensor was used for the determination of urea,L-...
Objective: L-asparaginase (L-ASP) is one of the indispensible medications used in the treatment of acute lymphoblastic leukemia (ALL); however, the allergic reactions caused by the drug limit its use. 52 patients (37 were low risk, 15 were high risk) who were followed for ALL be...
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