Communications Biology volume 4, Article number: 93 (2021) Cite this article 97k Accesses 1695 Altmetric Metrics details Abstract Emerging outbreak of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is a major threat to public health. The morbidity is increasing due to lack...
Asterisks on the x-axis mark proteins that have been identified in each replicate of the iA pulldown but in none of control or iQ replicates and thus represent highly significantly enriched proteins. a, enriched HDACs and proposed off-targets are highlighted (two sided t-test, p value ...
As a counterpoint, the authors do note that even though many molecular biology highly cited articles were done in 1976, there has been extremely much innovation since then however it may take a lot more in experiments and money to gain the level of citations that those papers produced, and ...
Facing the unknown problem of the Universes,Wenmang suddenly became Wenmang. In the unknown state, Wenmang learned from himself without a teacher (in fact, taking the Universes as a teacher), taking the Universes as a paper, taking existence and change as a pen, and using the Universes sou...
Jessica B. Spinelli1,2, Haejin Yoon1, Alison E. Ringel1, Sarah Jeanfavre2, Clary B. Clish2, Marcia C. Haigis1* 1.1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. 2.2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ...
Given the prevalence of stress biology mechanisms in cancer recurrence and metastatic disease, compounds that inhibit PERK represent a differentiated opportunity for the treatment of cancer. Small molecule PERK inhibitors have been previously documented in the patent literature10 as well as journal publicat...
New data is emerging from evolutionary anthropology and the neuroscience of social cognition on our species-specific hyper-cooperation (HC). This paper att
Not from the paper. But if you figure out a good way to calculate weights on this one, email me. Each node might affect the others with a certain delay. Being suicidal might make you feel guilty, but even if your last suicidal thought was fifteen minutes ago, you might still feel guil...
A typical protein structure-based drug design (SBDD) project starts from the protein sequence and builds a three-dimensional (3D) structure through structural biology or structure prediction. It then identifies binding pockets, including orthosteric sites or allosteric sites, and finally discovers active...
Decoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. This is well studied for PTMs of core histones but not for linker histone H1 in general and its ubiquitylation in p