research rigor, and feasibility of the proposed research without the distraction of administrative questions and 2) whether or not appropriate expertise and resources are available to conduct the research, thus mitigating the undue influence of the reputation of the institution...
Jessica B. Spinelli1,2, Haejin Yoon1, Alison E. Ringel1, Sarah Jeanfavre2, Clary B. Clish2, Marcia C. Haigis1* 1.1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. 2.2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. *↵*Corresponding author. ...
With the accumulation of large-scale molecular and cell biology datasets, coming from ever-growing literature, omics experiments and high-throughput screenings, new frameworks for integrative data analysis are necessary. For a given biological entity (e.g., a gene), we are now able to stack mul...
Decoding the role of histone posttranslational modifications (PTMs) is key to understand the fundamental process of epigenetic regulation. This is well studied for PTMs of core histones but not for linker histone H1 in general and its ubiquitylation in p
Targeted cancer therapy has become one of the most important medical methods because of the spreading and metastatic nature of cancer. Based on the introduction of AS1411 and its four-chain structure, this paper reviews the research progress in cancer de
We also offer International Advanced Subsidiary and Advanced Levels in Biology, Physics and Psychology, and in Mathematics and Further Mathematics. More information can be found on our website () on the Edexcel International Advanced Level pages. Pearson Edexcel International Advanced Subsidiary/Advanced...
The synthesis of novel N-substituted, benzimidazole-derived acrylonitriles 32–71 is illustrated in Scheme 1, starting from the ortho-chloronitrobenzenes 1–2. Scheme 1. Synthesis of benzimidazole acrylonitriles 32–71. By using uncatalyzed microwave-assisted amination in acetonitrile with an exces...
Taken together, there might be a need to further evaluate cut-off values in a larger set of serum and milk samples, and, if needed, adjust them, before the test scheme (bulk milk followed by individual milk samples) is implemented on a larger scale, such as in a control programme. The...
answers. The pattern of questions set is similar for every year and you should familiarise yourself with the pattern. Usually, the same type of questions will have similar mark scheme, so this can help you when answering exam questions. You should remember the answers for questions that are ...
In one of the reports, that will be filed later this week, environmental engineer Mark Tompkins, concluded that heavy rain has caused erosion at the border. He wrote that“Fisher Industries private bollard fence will fail during extreme high flow events,”and called the construction company’s ...