Acknowledgements This paper is dedicated to the memory of the late Herbert Steinbeißer, who passed away in 2014. He was involved in this project from its beginning in the 1990 s; the Dvl2 membrane recruitment experiments in animal caps were performed in his laboratory. We thank all ...
A typical protein structure-based drug design (SBDD) project starts from the protein sequence and builds a three-dimensional (3D) structure through structural biology or structure prediction. It then identifies binding pockets, including orthosteric sites or allosteric sites, and finally discovers active...
To the best of our knowledge, this paper is the first to study students’ overconfidence using monetary incentives to analyze self-chosen goals and post-dictions as reference points. We consider money as an effective incentive because, it is a non-satiable good and, as Croson (2005) points ...
The in silico approach to address the evolutionary cell biology of MICOS has reached saturation, necessitating functional data from other eukaryotic groups. To this end, we have undertaken the first study of MICOS composition and function outside of opisthokonts. We have chosen the pathogen ...
Many of these RBPs lack classical RNA-binding domains and assigned functions in RNA biology; we collectively refer to these as enigmRBPs (Beckmann et al., 2015). The intensively studied p62/sequestosome-1 is an excellent example of such an enigmRBP, whose RNA-binding properties was previously...
LIVE – OCTOBER 16 – DAY 1- Koch Institute Immune Engineering Symposium 2017, MIT, Kresge Auditorium Posted inAdaptive Immune Response to Biomaterials and Tissue Repair,Biological Engineering,CANCER BIOLOGY & Innovations in Cancer Therapy,Cancer-Immune Interactions,combination immunotherapies.,Conference Cov...
Centre for Invasion Biology, Department of Botany and Zoology, Stellenbosch University, Stellenbosch, South Africa David M. Richardson South African National Biodiversity Institute, Kirstenbosch Research Centre Cape Town, South Africa, Centre for Invasion Biology, Department of Botany and Zoology, Stellenbos...
Jessica B. Spinelli1,2, Haejin Yoon1, Alison E. Ringel1, Sarah Jeanfavre2, Clary B. Clish2, Marcia C. Haigis1* 1.1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. 2.2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ...
Plekhanov2, Mark I. Stockman5 & Vladimir P. Zharov1 Understanding cell biology greatly benefits from the development of advanced diagnostic probes. Here we introduce a 22-nm spaser (plasmonic nanolaser) with the ability to serve as a super-bright, water-soluble, biocompatible probe capable of ...
With the accumulation of large-scale molecular and cell biology datasets, coming from ever-growing literature, omics experiments and high-throughput screenings, new frameworks for integrative data analysis are necessary. For a given biological entity (e.g., a gene), we are now able to stack mul...