A typical protein structure-based drug design (SBDD) project starts from the protein sequence and builds a three-dimensional (3D) structure through structural biology or structure prediction. It then identifies binding pockets, including orthosteric sites or allosteric sites, and finally discovers active...
With the accumulation of large-scale molecular and cell biology datasets, coming from ever-growing literature, omics experiments and high-throughput screenings, new frameworks for integrative data analysis are necessary. For a given biological entity (e.g., a gene), we are now able to stack mul...
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Acknowledgements The studies were supported by grants from Academy of Finland (318327) and Sigrid Juselius Foundation for TTM. The...
As a counterpoint, the authors do note that even though many molecular biology highly cited articles were done in 1976, there has been extremely much innovation since then however it may take a lot more in experiments and money to gain the level of citations that those papers produced, and ...
Plant Biology* Plant Cell Walls Plant Stem Cells Root Development Auxin is a major phytohormone involved in regulating many aspects of seedling development, including cotyledon formation, hypocotyl cell elongation, meristem maintenance and root morphogenesis (1). In land plants, the response to auxin ...
Jessica B. Spinelli1,2, Haejin Yoon1, Alison E. Ringel1, Sarah Jeanfavre2, Clary B. Clish2, Marcia C. Haigis1* 1.1Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA. 2.2Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA. ...
需要金币:*** 金币(10金币=人民币1元) 剑桥国际联盟chemistry a level AS revisionInternational-A-Level-Chemistry-Spec.pdf 关闭预览 想预览更多内容,点击免费在线预览全文 免费在线预览全文 INTERNATIONAL ADVANCED LEVEL EDEXCEL INTERNATIONAL GCSE CHEMISTRY ECONOMICS SPECIFICATION SPECIFICATION Pearson Edexcel Internat...
(This article belongs to the Section Entropy and Biology) Download keyboard_arrow_down Browse Figures Versions Notes Abstract While approaches based on physical grounds (such as the drift-diffusion model—DDM) have been exhaustively used in psychology and neuroscience to describe perceptual decision ...
In this paper, the diseases of bone tissue are described, in the treatment of which calcium phosphate cements can be used as carriers of functional substances. Knowledge of the pathogenesis of diseases and the methods of treatment used—in particular, drug therapy—can help develop the concepts ...
When you have understood all topics, you have to do past year A Level questions. They are available on the internet. After doing the questions, refer to the mark scheme and do self marking. The mark schemes can usually be found on the same website as the past year questions. ...