is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we describe a microglial subtype expressing the enzyme arginase-1 (ARG1; that is, ARG1+ microglia) that is found predominantly in ...
2023年5月11日卡罗林斯卡医学院Bertrand Joseph研究团队在Nature Neuroscience杂志上发表文章“ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain”,揭示了表达ARG1的小胶质细胞显示出独特的分子特征并调节小鼠大脑的出生后发育和功能。 复杂的...
Molecular diversity of microglia, the resident immune cells in the CNS, is reported. Whether microglial subsets characterized by the expression of specific proteins constitute subtypes with distinct functions has not been fully elucidated. Here we describe a microglial subtype expressing the enzyme arginas...
Here we describe a microglial subtype expressing the enzyme arginase-1 (ARG1; that is, ARG1+microglia) that is found predominantly in the basal forebrain and ventral striatum during early postnatal mouse development. ARG1+microglia are enriched in phagocytic inclusions and exhibit a distinct molecular...
which is critical for pathogen control. ARG1 mainly expresses in neurons in a normal brain. The expression of ARG1 increases in microglia/macrophages and astrocytes early after CNS injuries. ARG1 has been regarded as a marker for beneficial microglia/macrophages and possesses antiinflammatory and tissu...
Product Datasheets Product Datasheet COA SDS Related Research Areas Macrophage Activation Markers Microglia Activation Markers Myeloid-derived Suppressor Cells (MDSC) Search Immunotherapy-related Enzymes
2023年5月11日卡罗林斯卡医学院Bertrand Joseph研究团队在Nature Neuroscience杂志上发表文章“ARG1-expressing microglia show a distinct molecular signature and modulate postnatal development and function of the mouse brain”,揭示了表达ARG1的小胶质细胞显示出独特的分子特征并调节小鼠大脑的出生后发育和功能。
Arg1 and iNOS PCR gene expression assays of αSyn-preconditioned microglia stimulated with Pam3 or ssRNA.Cintia RoodveldtAdahir LabradorGarridoElena GonzalezReyChristian C. LachaudTim GuilliamsRafael FernandezMontesinosAlicia BenitezRondanGema Robledo...
However, the regulatory role of endogenous EVs on the phagocytic capacity of microglia post-ICH remains elusive. Utilising multi-omics analysis of brain tissue-derived EVs proteomics and single-cell RNA sequencing, this study identified that bone marrow-derived macrophages (BMDMs) potentially enhance ...